Adhesion remodeling underlying tissue morphogenesis

Trends in Cell Biology
Thomas Lecuit


Cell-adhesion molecules localized at adherens junctions (AJs) maintain the polarized architecture of epithelial cells but limit their movements. The morphogenesis of a developing epithelium is associated with the control of both cell shape and cell contacts. Epithelial cells remodel their contacts, and intercellular adhesion controlled by cadherin molecules is spatially and temporally regulated. Cell shape depends, in part, on the regulation of cell adhesion between different groups of cells. Patterned epithelial cell movements such as those that occur during cell intercalation--a universal process whereby cells exchange neighbors--rely on the polarized remodeling of AJs. Recent studies show that the understanding of adhesion will benefit from studies of developing organisms in which adhesion is regulated.


May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S H JaffeG M Edelman
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D R FriedlanderG M Edelman
May 1, 1987·The Journal of Cell Biology·J L DubandJ P Thiery
Jul 1, 1994·The Journal of Cell Biology·W M Brieher, Barry M Gumbiner
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·Malcolm S Steinberg, M Takeichi
Jan 1, 1993·Genes & Development·P E YoungD P Kiehart
Nov 18, 1998·Current Opinion in Cell Biology·C L Adams, W James Nelson
Mar 1, 1993·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·J A Glazier, F Graner
Dec 10, 1999·Developmental Biology·B LeungJ R Priess
May 16, 2000·Nature·Carl-Philipp HeisenbergStephen W Wilson
May 16, 2000·Nature·John B WallingfordR M Harland
Nov 13, 2001·Developmental Cell·Jacek TopczewskiLilianna Solnica-Krezel
Jan 16, 2002·The Journal of Cell Biology·Carien M Niessen, Barry M Gumbiner
Feb 16, 2002·Developmental Biology·Judith A Lengyel, D D Iwaki
Jul 10, 2002·Nature Cell Biology·Jason R JessenLilianna Solnica-Krezel
Aug 15, 2002·Current Biology : CB·José CasalP A Lawrence
Dec 10, 2002·Science·Elisabeth Knust, Olaf Bossinger
Jan 23, 2003·Development·Nathalia S GlickmanRichard J Adams
Jan 24, 2003·Nature·Dali MaJeffrey D Axelrod
Feb 4, 2003·Nature Cell Biology·Thomas Lecuit, Fanny Pilot
Mar 21, 2003·Developmental Biology·Duke DuguayMalcolm S Steinberg
Apr 5, 2003·Mechanisms of Development·Beate KilianCarl Philipp Heisenberg
Jul 23, 2003·Development·Filipa Carreira-BarbosaMasazumi Tada
Jul 31, 2003·Current Opinion in Genetics & Development·Domingos Henrique, François Schweisguth
Jan 20, 2004·Journal of Cell Science·Manolis Fanto, Helen McNeill
Mar 20, 2004·Developmental Cell·Jennifer A Zallen, Eric Wieschaus
Jun 3, 2004·Mechanisms of Development·Jamie C RusconiRoss Cagan
Jul 15, 2004·Journal of Cell Science·Thomas Lecuit
Oct 8, 2004·Nature·Takashi Hayashi, Richard W Carthew


Aug 1, 2012·Journal of Signal Transduction·Cristina BertocchiRonen Zaidel-Bar
Dec 13, 2006·Future Oncology·Amber YasmeenAla-Eddin Al Moustafa
Nov 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jos KäferFrançois Graner
Jun 23, 2006·PLoS Computational Biology·Jos KäferAthanasius F M Marée
Jun 29, 2007·Molecular Biology of the Cell·Stanislav N SamarinAsma Nusrat
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kentaro Abe, Masatoshi Takeichi
Jan 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sascha HilgenfeldtRichard W Carthew
May 6, 2009·Annual Review of Biomedical Engineering·Martin L Yarmush, Kevin R King
Jun 12, 2009·Molecular Biology of the Cell·Julia Christina GrossAnna Starzinski-Powitz
Sep 22, 2010·PloS One·Yousef JamaliMohammad R K Mofrad
May 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·C MeghanaMaithreyi Narasimha
Jun 22, 2012·Journal of Cell Science·Hamid TabdiliDeborah Leckband
Mar 14, 2007·Médecine sciences : M/S·Isabelle Bécam, Jean-René Huynh
Aug 17, 2011·The Journal of Cell Biology·Katsutoshi TaguchiMasatoshi Takeichi
Apr 13, 2011·The Journal of Cell Biology·Tomoki YanoSachiko Tsukita
Apr 1, 2010·Cell Communication & Adhesion·M F IzaguirreV H Casco
Nov 17, 2009·Comptes rendus biologies·Juhui WangIsabelle Hue
Jul 21, 2009·Current Opinion in Cell Biology·Benjamin Boettner, Linda Van Aelst
Jul 13, 2007·Current Opinion in Genetics & Development·Malcolm S Steinberg
Dec 1, 2006·Trends in Cell Biology·Ulrich Tepass, Kathryn P Harris
Jan 5, 2006·EMBO Reports·Marc Neumann, Markus Affolter
Feb 28, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Masanari Takamiya, Jose A Campos-Ortega
Apr 24, 2007·Journal of Biomedical Materials Research. Part a·D D AtehP Vadgama
Oct 5, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Kevin S Kolahi, Mohammad R K Mofrad
Nov 30, 2011·Biotechnology and Bioengineering·Pooja IyerSundararajan V Madihally
Jun 30, 2006·Current Opinion in Cell Biology·Gregory Emery, Juergen A Knoblich
Dec 4, 2014·Science Signaling·Zhenhuan GuoRonen Zaidel-Bar
Nov 26, 2008·Current Biology : CB·Emmanuel CaussinusMarkus Affolter
Jul 12, 2005·Current Biology : CB·Thomas Lecuit
Apr 18, 2007·Current Biology : CB·Sarah Woolner
Sep 5, 2006·Biochimica Et Biophysica Acta·Kanyan XiaoAndrew P Kowalczyk
Nov 5, 2013·Developmental Cell·Adam PackardFrank Costantini
Feb 24, 2007·Developmental Biology·Amalia RosnerBaruch Rinkevich
Jan 24, 2006·Developmental Biology·Dana RashidRoger Bradley
Dec 1, 2006·Developmental Biology·Shuyi Nie, Chenbei Chang
Feb 18, 2010·Biophysical Journal·Benoit LadouxRené-Marc Mège
Nov 19, 2014·PLoS Biology·Beth L PruittW James Nelson
Oct 4, 2016·Frontiers in Cell and Developmental Biology·Hideru Togashi
Apr 11, 2017·Experimental Cell Research·Hideru Togashi, Sayaka Katsunuma
Jan 20, 2017·Nature·Darren GilmourMaria Leptin
Aug 16, 2017·Development·Amanda Ochoa-EspinosaMarkus Affolter
May 16, 2014·Nature Reviews. Molecular Cell Biology·Masatoshi Takeichi
Aug 22, 2006·The Journal of Biological Chemistry·Karin M KirschnerHolger Scholz
Oct 3, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Robert J Major, Kenneth D Irvine
Nov 15, 2014·Biology Open·Paul S Murray, Ronen Zaidel-Bar
Oct 28, 2008·Development·Matthias Hammerschmidt, Doris Wedlich
Apr 3, 2013·Journal of Cell Science·Ronen Zaidel-Bar

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