Cell-adhesion molecules localized at adherens junctions (AJs) maintain the polarized architecture of epithelial cells but limit their movements. The morphogenesis of a developing epithelium is associated with the control of both cell shape and cell contacts. Epithelial cells remodel their contacts, and intercellular adhesion controlled by cadherin molecules is spatially and temporally regulated. Cell shape depends, in part, on the regulation of cell adhesion between different groups of cells. Patterned epithelial cell movements such as those that occur during cell intercalation--a universal process whereby cells exchange neighbors--rely on the polarized remodeling of AJs. Recent studies show that the understanding of adhesion will benefit from studies of developing organisms in which adhesion is regulated.
cDNAs of cell adhesion molecules of different specificity induce changes in cell shape and border formation in cultured S180 cells
Differential effects of the cytoplasmic domains of cell adhesion molecules on cell aggregation and sorting-out
Cell sorting-out is modulated by both the specificity and amount of different cell adhesion molecules (CAMs) expressed on cell surfaces
The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex
Does differential adhesion govern self-assembly processes in histogenesis? Equilibrium configurations and the emergence of a hierarchy among populations of embryonic cells
Ontogenetic expression of cell adhesion molecules: L-CAM is found in epithelia derived from the three primary germ layers
Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression
Spatial and temporal dissection of immediate and early events following cadherin-mediated epithelial cell adhesion
armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila
Mechanism for transition from initial to stable cell-cell adhesion: kinetic analysis of E-cadherin-mediated adhesion using a quantitative adhesion assay
Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion
Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein
Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton
The zinc finger protein DIE-1 is required for late events during epithelial cell rearrangement in C. elegans
The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension
Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye
Asymmetric localization of frizzled and the determination of notch-dependent cell fate in the Drosophila eye
In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis
Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion
The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor
Activity and distribution of paxillin, focal adhesion kinase, and cadherin indicate cooperative roles during zebrafish morphogenesis
Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein
Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing
Moving forward moving backward: directional sorting of chemotactic cells due to size and adhesion differences
EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt
F-actin-based extensions of the head cyst cell adhere to the maturing spermatids to maintain them in a tight bundle and prevent their premature release in Drosophila testis
E-cadherin surface levels in epithelial growth factor-stimulated cells depend on adherens junction protein shrew-1
Integrin adhesion drives the emergent polarization of active cytoskeletal stresses to pattern cell delamination
Genetic control of intercellular adhesion or how cadherins shape the fruitfly Drosophila melanogaster
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner
Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling
The use of sodium hyaluronate-carboxymethylcellulose to prevent postoperative mastication pain from harvesting of temporalis fascia
Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium
Heterocellular interaction enhances recruitment of alpha and beta-catenins and ZO-2 into functional gap-junction complexes and induces gap junction-dependant differentiation of mammary epithelial cells
Hedgehog signalling controls zebrafish neural keel morphogenesis via its level-dependent effects on neurogenesis
Increased matrix synthesis by fibroblasts with decreased proliferation on synthetic chitosan-gelatin porous structures
Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells
Downregulation of Notch mediates the seamless transition of individual Drosophila neuroepithelial progenitors into optic medullar neuroblasts during prolonged G1
The Drosophila p21 activated kinase Mbt regulates the actin cytoskeleton and adherens junctions to control photoreceptor cell morphogenesis
Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis
Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing
Segmentation and tracking of adherens junctions in 3D for the analysis of epithelial tissue morphogenesis
Software-based measurement of thin filament lengths: an open-source GUI for Distributed Deconvolution analysis of fluorescence images
Making the connection - shared molecular machinery and evolutionary links underlie the formation and plasticity of occluding junctions and synapses
Heterophilic cell-cell adhesion of atypical cadherins Fat and Dachsous regulate epithelial cell size dynamics during Drosophila thorax morphogenesis.
Collective cell traction force analysis on aligned smooth muscle cell sheet between three-dimensional microwalls
Development of the duct system during exocrine pancreas differentiation in the grass snake Natrix natrix (Lepidosauria, Serpentes)
Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells
The Wilms tumor suppressor Wt1 promotes cell adhesion through transcriptional activation of the alpha4integrin gene.
Localization and requirement for Myosin II at the dorsal-ventral compartment boundary of the Drosophila wing
Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape
The Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc
A cellular process that includes asymmetric cytokinesis remodels the dorsal tracheal branches in Drosophila larvae
Cadherins and Catenins
Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.
Adhesion Molecules in Health and Disease
Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.
Actin, Myosin & Cell Movement
Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.
Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.
An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.
Biophysics of Adhesion
Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.