Adhesion to and invasion of pulmonary epithelial cells by the F15/LAM4/KZN and Beijing strains of Mycobacterium tuberculosis

Journal of Medical Microbiology
Olubisi T AshiruA Willem Sturm

Abstract

Globally, specific genotypes of Mycobacterium tuberculosis have been shown to dominate in patients, suggesting that these are more successful pathogens. One such genotype, the F15/LAM4/KZN (KZN) family of M. tuberculosis, has predominated in KwaZulu-Natal, South Africa, since the early 1990s. This strain recently evolved from multidrug-resistant to extensively drug-resistant (XDR). The ability of M. tuberculosis strains belonging to the Beijing family, the KZN family, strains with unique DNA fingerprint patterns and laboratory strains (H37Rv and H37Ra) to adhere to and invade a human alveolar (A549) and a human bronchial (BBM) epithelial cell line was investigated. All strains displayed greater adhesion to and invasion of A549 cells as compared to BBM cells. The Beijing and KZN strains combined showed greater adhesion (28 %) than the unique strains (5 %) (P <0.05). The XDR variant of KZN invaded A549 cells more effectively than the other isolates. These results suggest that the successful spread of the Beijing and KZN strains might be related to their interaction with alveolar epithelium.

References

Aug 1, 1991·The American Review of Respiratory Disease·P R Rogol
Apr 1, 1996·Infection and Immunity·L E Bermudez, J Goodman
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·S SreevatsanJ M Musser
Mar 5, 1998·The New England Journal of Medicine·S E ValwayI M Onorato
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·N W Schluger, W N Rom
Aug 7, 1999·The Journal of Infectious Diseases·D van SoolingenJ D van Embden
Jul 21, 2001·The New England Journal of Medicine·P M Small, P I Fujiwara
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·Stephen E WeisPeter F Barnes
Jul 27, 2002·Emerging Infectious Diseases·Judith R GlynnDick van Soolingen
Jun 6, 2003·Microbes and Infection·Maria Cristina Vidal PessolaniFranco D Menozzi
Aug 7, 2003·Microbial Pathogenesis·Blanca Estela García-PérezJulieta Luna-Herrera
Aug 21, 2003·Microbial Pathogenesis·Marco Antonio Velasco-VelázquezJosé Agramonte-Hevia
May 4, 2005·Trends in Cell Biology·Liem Nguyen, Jean Pieters
Jun 21, 2005·Emerging Infectious Diseases·Helmi MardassiKoussay Dellagi
Nov 1, 2006·Emerging Infectious Diseases·Laurent X NouvelBrigitte Gicquel
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christopher J AlteriRichard L Friedman
May 18, 2007·Journal of Clinical Microbiology·Sahal A M Al-HajojNalin Rastogi
Nov 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Manormoney Pillay, A Willem Sturm
Dec 24, 2008·BMC Infectious Diseases·Horng-Yunn DouJang-Jih Lu

❮ Previous
Next ❯

Citations

Feb 26, 2014·Emerging Infectious Diseases·Neel R GandhiN Sarita Shah
Jan 10, 2016·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Saiyur RamsugitManormoney Pillay
Apr 21, 2010·FEMS Immunology and Medical Microbiology·Violeta ValchevaNalin Rastogi
Feb 26, 2016·Journal of Medical Microbiology·Michelle B RyndakSuman Laal
Oct 19, 2016·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Rahul PalZeeshan Fatima
Jan 19, 2019·FEMS Microbiology Reviews·Margherita BertuzziElaine M Bignell
Sep 10, 2019·Frontiers in Cellular and Infection Microbiology·Michelle B Ryndak, Suman Laal
Feb 23, 2021·Frontiers in Microbiology·Anna Allué-GuardiaJordi B Torrelles
Apr 10, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Taetso Nkwagatse, A Willem Sturm
Jan 21, 2021·Journal of Bacteriology·Albertus ViljoenYves F Dufrêne
Aug 28, 2021·Diagnostics·Darius Riziki MartinMervin Meyer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.