Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Sys HasslundHani Awad

Abstract

Reconstruction of flexor tendons often results in adhesions that compromise joint flexion. Little is known about the factors involved in the formation of flexor tendon graft adhesions. In this study, we developed and characterized a novel mouse model of flexor digitorum longus (FDL) tendon reconstruction with live autografts or reconstituted freeze-dried allografts. Grafted tendons were evaluated at multiple time points up to 84 days post-reconstruction. To assess the flexion range of the metatarsophalangeal joint, we developed a quantitative outcome measure proportional to the resistance to tendon gliding due to adhesions, which we termed the Gliding Coefficient. At 14 days post-grafting, the Gliding Coefficient was 29- and 26-fold greater than normal FDL tendon for both autografts and allografts, respectively (p < 0.001), and subsequently doubled for 28-day autografts. Interestingly, there were no significant differences in maximum tensile force or stiffness between live autograft and freeze-dried allograft repairs over time. Histologically, autograft healing was characterized by extensive remodeling and exuberant scarring around both the ends and the body of the graft, whereas allograft scarring was abundant only near the gr...Continue Reading

References

Jan 1, 1992·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·R H GelbermanD Amiel
Jan 1, 1988·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·R A WainerG G Poehling
Jul 1, 1988·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·S DovelleJ A Chow
Mar 1, 1982·The Journal of Hand Surgery·A D Potenza, M C Herte
Jan 1, 1981·Journal of Pediatric Orthopedics·R W Bright, W T Green
Jan 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S O AbrahamssonF Harwood
May 1, 1993·The Journal of Hand Surgery·K L SilfverskiöldA H Törnvall
Apr 7, 1999·Acta Orthopaedica Scandinavica·P Aspenberg, C Forslund
Jun 12, 1999·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·J S Taras, M J Lamb
Nov 24, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M J SilvaR H Gelberman
May 18, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M BidderM I Boyer
Oct 21, 2000·The Journal of Bone and Joint Surgery. British Volume·U KhanD A McGrouther
Jun 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B MikicE B Hunziker
Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M I BoyerS R Cai
May 11, 2005·Hand Clinics·Martin I Boyer
Jul 11, 2006·The Journal of the American Academy of Orthopaedic Surgeons·Soma I Lilly, Terry M Messer

❮ Previous
Next ❯

Citations

Sep 13, 2013·Tissue Engineering. Part a·Yasuhiro OzasaChunfeng Zhao
Feb 27, 2014·Hand : Official Journal of the American Association for Hand Surgery·Spencer J StanburyJohn C Elfar
May 28, 2013·The Journal of Hand Surgery·David B DrakeBrent R DeGeorge
Dec 17, 2014·Advanced Drug Delivery Reviews·A J LomasD I Zeugolis
Dec 15, 2015·The Journal of Hand Surgery·Alayna E LoiselleWarren C Hammert
Oct 17, 2009·The American Journal of Pathology·Jason K F WongDuncan A McGrouther
Dec 4, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Alayna E LoiselleRegis J O'Keefe
Dec 24, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hiromichi OmaePeter C Amadio
Mar 12, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Alayna E LoiselleRegis J O'Keefe
Sep 16, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Evan B KatzelRegis J O'Keefe
Dec 10, 2013·Bone·Subhash C JunejaArchibald S Perkins
Jan 17, 2017·Tissue Engineering. Part B, Reviews·Sushmitha Durgam, Matthew Stewart
Apr 19, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jessica E AckermanAlayna E Loiselle
Jan 11, 2013·The Journal of Hand Surgery, European Volume·N AlamJ K F Wong
Aug 13, 2015·The Journal of Hand Surgery, European Volume·R WongJ K F Wong
Sep 22, 2010·Macromolecular Bioscience·Franklin T MoutosFarshid Guilak
Mar 15, 2019·Annals of Plastic Surgery·Roberto A MartinezBrent R DeGeorge
Jun 25, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jessica E AckermanAlayna E Loiselle
Jun 3, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Katherine T BestAlayna E Loiselle
Jun 30, 2012·Clinical Orthopaedics and Related Research·Furkan E Karabekmez, Chunfeng Zhao
Nov 4, 2008·The Journal of the American Academy of Orthopaedic Surgeons·Andrew N PollakUNKNOWN Extremity War Injuries III Session Moderators
May 28, 2019·ELife·Jessica E AckermanAlayna E Loiselle
Feb 6, 2017·Journal of Materials Science. Materials in Medicine·Marta Bottagisio, Arianna B Lovati
Feb 9, 2021·Plastic and Reconstructive Surgery. Global Open·Ashley L TitanMichael T Longaker
Nov 23, 2016·Foot and Ankle Clinics·Jessica A CottrellJ Patrick O'Connor

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Molecular Therapy : the Journal of the American Society of Gene Therapy
Patrick BasileHani Awad
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Alayna E LoiselleRegis J O'Keefe
Journal of the American Society of Nephrology : JASN
Shiguang LiuL Darryl Quarles
© 2021 Meta ULC. All rights reserved