Adhesive Cements That Bond Soft Tissue Ex Vivo

Materials
Xiuwen LiuHakan Engqvist

Abstract

The aim of the present study was to evaluate the soft tissue bond strength of a newly developed, monomeric, biomimetic, tissue adhesive called phosphoserine modified cement (PMC). Two types of PMCs were evaluated using lap shear strength (LSS) testing, on porcine skin: a calcium metasilicate (CS1), and alpha tricalcium phosphate (αTCP) PMC. CS1 PCM bonded strongly to skin, reaching a peak LSS of 84, 132, and 154 KPa after curing for 0.5, 1.5, and 4 h, respectively. Cyanoacrylate and fibrin glues reached an LSS of 207 kPa and 33 kPa, respectively. αTCP PMCs reached a final LSS of ≈110 kPa. In soft tissues, stronger bond strengths were obtained with αTCP PMCs containing large amounts of amino acid (70-90 mol%), in contrast to prior studies in calcified tissues (30-50 mol%). When αTCP particle size was reduced by wet milling, and for CS1 PMCs, the strongest bonding was obtained with mole ratios of 30-50% phosphoserine. While PM-CPCs behave like stiff ceramics after setting, they bond to soft tissues, and warrant further investigation as tissue adhesives, particularly at the interface between hard and soft tissues.

References

Jul 1, 1992·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·D H SierraS Huang
Nov 28, 2000·Journal of Biomedical Materials Research·T SekineT Kiyotani
Nov 17, 2001·Plastic and Reconstructive Surgery·L J CurrieR Martin
Aug 31, 2004·Journal of Materials Science. Materials in Medicine·A ReinstorfP Simon
Feb 19, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Ronald MaiBernd Stadlinger
Apr 16, 2008·The American Journal of Emergency Medicine·Adam J SingerJudd E Hollander
Sep 23, 2008·Biomedizinische Technik. Biomedical Engineering·Ronald MaiBernd Stadlinger
Dec 2, 2008·Macromolecular Bioscience·Hui ShaoRussell J Stewart
Dec 25, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Antonio Merolli, Matteo Santin
Feb 23, 2010·Bone·Philipp J ThurnerTamara Alliston
Jul 7, 2010·Journal of Tissue Engineering and Regenerative Medicine·Liliana OfferReinhard Schnettler
Aug 12, 2010·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·William D Spotnitz, Sandra Burks
Sep 17, 2010·Journal of Biomedical Materials Research. Part a·Corina VaterMichael Gelinsky
Oct 6, 2010·Biomacromolecules·John L MurphyBruce P Lee
Jun 30, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ahmad R HadbaJohn Kennedy
Jun 7, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ninette TödtmannUwe Eckelt
Oct 17, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Ondřej NikelDeepak Vashishth
Jan 29, 2014·Journal of Cutaneous and Aesthetic Surgery·Luluah Al-Mubarak, Mohammed Al-Haddab
Apr 9, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gareth Wynn-JonesMichael P Hofmann
Feb 5, 2015·Chemical Society Reviews·C Ghobril, M W Grinstaff
Apr 22, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Francesca ScognamiglioSergio Paoletti
Oct 27, 2015·Journal of Applied Crystallography·Nicola Doebelin, Reinhard Kleeberg
Dec 26, 2015·Journal of Materials Science. Materials in Medicine·Yali JiLei Zhu
Jan 31, 2017·Acta Biomaterialia·Biji BalakrishnanAthipettah Jayakrishnan
Jun 25, 2017·Biomaterials·Alexander AssmannNasim Annabi
Sep 2, 2017·Biomacromolecules·Vrushali Bhagat, Matthew L Becker
Jun 26, 2018·Advanced Healthcare Materials·Alina KirillovaKen Gall
Oct 24, 2018·Plastic and Reconstructive Surgery. Global Open·Shiho NakagawaKotaro Yoshimura
Nov 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Chuying MaJian Yang
Dec 14, 2018·Materials·Michael Pujari-PalmerHakan Engqvist
Mar 4, 2013·Biomaterials Science·Lígia Pereira BréWenxin Wang
May 7, 2019·BMC Biomedical Engineering·Philip ProcterHåkan Engqvist

❮ Previous
Next ❯

Citations

Oct 29, 2020·Advanced Healthcare Materials·Alina KirillovaKen Gall
Mar 4, 2020·ACS Central Science·Christopher D SpicerMolly M Stevens
Nov 26, 2021·Frontiers in Bioengineering and Biotechnology·Philip ProcterSune Larsson

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

SPSS
Trapezium Lite
Mastersizer
Profex

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Gastrointestinal Endoscopy
Bret PetersenTechnology Assessment Committee, American Society for Gastrointestinal Endoscopy
Shanghai kou qiang yi xue = Shanghai journal of stomatology
Hu ZhengDong-wei Han
© 2021 Meta ULC. All rights reserved