Adhesive strength of bone-implant interfaces and in-vivo degradation of PHB composites for load-bearing applications

Journal of the Mechanical Behavior of Biomedical Materials
M MeischelStefanie Stanzl-Tschegg

Abstract

Aim of this study was to evaluate the response of bone to novel biodegradable polymeric composite implants in the femora of growing rats. Longitudinal observation of bone reaction at the implant site (BV/TV) as well as resorption of the implanted pins were monitored using in vivo micro-focus computed tomography (µCT). After 12, 24 and 36 weeks femora containing the implants were explanted, scanned with high resolution ex vivo µCT, and the surface roughness of the implants was measured to conclude on the ingrowth capability for bone tissue. Scanning electron microscope (SEM) and energy dispersive X-ray spectroscopy (EDX) were used to observe changes on the surface of Polyhydroxybutyrate (PHB) during degradation and cell ingrowth. Four different composites with zirconium dioxide (ZrO2) and Herafill(®) were compared. After 36 weeks in vivo, none of the implants did show significant degradation. The PHB composite with ZrO2 and a high percentage (30%) of Herafill® as well as the Mg-alloy WZ21 showed the highest values of bone accumulation (increased BV/TV) around the implant. The lowest value was measured in PHB with 3% ZrO2 containing no Herafill®. Roughness measurements as well as EDX and SEM imaging could not reveal any changes o...Continue Reading

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Citations

Feb 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martin Koller
Aug 30, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Guo-Qiang Chen, Junyu Zhang
Sep 25, 2019·Bioengineering·Alejandra Rodriguez-Contreras
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Jan 31, 2021·Bioresource Technology·Vipin Chandra KaliaJung-Kul Lee
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Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Mehrshad MehrpouyaValérie Langlois

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