Adipocyte-derived hormones, cytokines, and mediators.

Endocrine
Cristina M Rondinone

Abstract

Adipose tissue is responsive to both central and peripheral metabolic signals and is itself capable of secreting a number of proteins. These adipocyte-specific or enriched proteins, termed adipokines, have been shown to have a variety of local, peripheral, and central effects. These secreted proteins, which include tumor necrosis factor (TNF)-alpha, resistin, IL-6, IL-8, acylation-stimulating protein (ASP), angiotensinogen, plasminogen activator inhibitor-1 (PAI-1) ("bad" adipokines) and leptin, adiponectin ("good" adipokines) seem to play important regulatory roles in a variety of complex processes, including fat metabolism, feeding behavior, hemostasis, vascular tone, energy balance, and insulin sensitivity, but none is without controversy regarding its respective mechanism and scope of action. The present review is focused on the effects of free fatty acids and a restricted number of adipokines, which have been implicated in vascular (angiotensinogen, PAI-1) and energy and glucose homeostasis (ASP, TNFalpha, IL-6, resistin, leptin, adiponectin).

Citations

Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Jun-Ichi YamakawaTsugiyasu Kanda
Feb 9, 2012·Journal of the National Cancer Institute·Dingzhi Wang, Raymond N Dubois
Apr 7, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Takashi Akamizu, Kenji Kangawa
Sep 8, 2006·Gut·Laurent Peyrin-BirouletPierre Desreumaux
Aug 27, 2009·American Journal of Physiology. Endocrinology and Metabolism·Maziyar SaberiJerrold M Olefsky
May 24, 2011·Journal of Obesity·Anis AmirhakimiGholamhosein Amirhakimi
Jan 15, 2013·Journal of Nutrition and Metabolism·Guido Di DalmaziValentina Vicennati
Feb 5, 2011·The Journal of Clinical Investigation·Guorui HuangDaniel S Greenspan
Mar 9, 2010·Italian Journal of Pediatrics·Giuseppe LatiniLorenzo Iughetti
Aug 7, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Sheryl F VondracekConnie Valdez
Jun 27, 2013·World Journal of Gastroenterology : WJG·Giovanni Tarantino, Carmine Finelli
Mar 20, 2008·Clinical & Developmental Immunology·Isabelle WolowczukCorinne Grangette
Jul 14, 2010·European Journal of Medical Research·E WysockaH Batura-Gabryel
Apr 8, 2020·Frontiers in Physiology·Syaza Hazwany AzharVeronique Angeli
Mar 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuchika TakeishiIsao Kubota
Jun 27, 2007·Alimentary Pharmacology & Therapeutics·I T Johnson, E K Lund
Aug 23, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A P Lima-LeopoldoA C Cicogna
Feb 26, 2009·The American Journal of Gastroenterology·Douglas K RexUNKNOWN American College of Gastroenterology
Jul 16, 2009·Experimental Dermatology·Burkhard PoeggelerRalf Paus
Jun 22, 2010·Expert Opinion on Biological Therapy·Gérald E PiérardPascale Quatresooz
May 1, 2010·American Journal of Clinical Dermatology·Susana CoimbraAlice Santos-Silva
Oct 4, 2011·PloS One·Dana C BorcherdingNira Ben-Jonathan
Nov 26, 2011·Expert Review of Clinical Pharmacology·Xiao-Yan ZhuXin Ni
Jun 19, 2013·Annals of the Rheumatic Diseases·Matteo Nicola Dario Di MinnoUNKNOWN CaRRDs Study Group
Mar 21, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·K C J YuenM C Riddle
May 28, 2013·Applied Biochemistry and Biotechnology·Tae-Wook Kim, Jeong-Beom Lee
Oct 29, 2013·The Journal of Pharmacology and Experimental Therapeutics·Dana K SindelarDonald R Gehlert
Nov 2, 2013·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·J SantosE Costa
Jun 7, 2016·The Tohoku Journal of Experimental Medicine·Chavarin AmaraseNoppachart Limpaphayom
Apr 2, 2017·Current Diabetes Reports·G MazziottiA Giustina
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina L SherryGregory G Freund
Jan 24, 2009·Applied Biochemistry and Biotechnology·F XuK J L Burg
Aug 16, 2008·International Journal of Colorectal Disease·Anna VaskůJulie Bienertová-Vasků
Mar 27, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·S CoimbraA Santos-Silva
Sep 23, 2009·International Journal of Clinical Practice·L VizioliA Muscari

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