Adipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes

Scientific Reports
Isabel GrauperaPere Ginès

Abstract

Fatty-acid-binding proteins (FABPs) are small intracellular proteins that coordinate lipid-mediated processes by targeting metabolic and immune response pathways. The aim of the study was to investigate plasma FABPs levels and their relationship with clinical outcomes in cirrhosis. Plasma levels of L-FABP1(liver and kidney), I-FABP2(intestine), and A-FABP4(adipocyte and macrophages) were measured in 274 patients with decompensated cirrhosis. Hepatic gene expression of FABPs was assessed in liver biopsies from patients with decompensated cirrhosis and in liver cell types from mice with cirrhosis. Immunohistochemistry of A-FABP4 in human liver biopsy was also performed. Plasma levels of FABPs were increased in patients with decompensated cirrhosis compared to those of healthy subjects (L-FABP1: 25 (17-39) vs 10 (9-17) ng/mL p = 0.001, I-FABP2: 1.1 (0.5-2.1) vs 0.6 (0.4-1) ng/mL p = 0.04 and A-FABP4: 37 (20-68) vs 16 (11-33) ng/mL p = 0.002), respectively. Increased A-FABP4 levels were associated with complications of cirrhosis, acute-on-chronic liver failure and poor survival. Hepatic A-FABP4 gene expression was upregulated in decompensated cirrhosis. Macrophages were the main liver cell that over-expressed A-FABP4 in experimenta...Continue Reading

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Citations

Apr 19, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aline de ContiIgor P Pogribny
Aug 6, 2020·International Journal of Molecular Sciences·Satoshi WashinoTomoaki Miyagawa
Mar 27, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Lung-Yi MakWai-Kay Seto
Mar 23, 2021·Journal of Clinical and Experimental Hepatology·Anand V KulkarniPadaki Nagaraja Rao
May 14, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Rong JinBing Li

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Methods Mentioned

BETA
PCR
biopsies
biopsy
ELISA
flow cytometry

Software Mentioned

SPSS

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