Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growth

The Journal of Clinical Investigation
J A LevineT O'Brien

Abstract

Adipose tissue growth results from de novo adipocyte recruitment (hyperplasia) and increased size of preexisting adipocytes. Adipocyte hyperplasia accounts for the severalfold increase in adipose tissue mass that occurs throughout life, yet the mechanism of adipocyte hyperplasia is unknown. We studied the potential of macrophage colony-stimulating factor (MCSF) to mediate adipocyte hyperplasia because of the profound effects MCSF exerts on pluripotent cell recruitment and differentiation in other tissues. We found that MCSF mRNA and protein were expressed by human adipocytes and that adipocyte MCSF expression was upregulated in rapidly growing adipose tissue that encircled acutely inflamed bowel and in adipose tissue from humans gaining weight (4-7 kg) with overfeeding. Localized overexpression of adipocyte MCSF was then induced in rabbit subcutaneous adipose tissue in vivo using adenoviral-mediated gene transfer. Successful overexpression of MCSF was associated with 16-fold increases in adipose tissue growth compared with a control adenovirus expressing beta-galactosidase. This occurred in the absence of increased cell size and in the presence of increased nuclear staining for MIB-1, a marker of proliferation. We conclude that...Continue Reading

References

Jan 1, 1992·Annual Review of Nutrition·G AilhaudR Négrel
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M R SureshC Milstein
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·J D SmithM Miyata
Sep 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·J P BastardB Hainque
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·J W Pollard, L Hennighausen
May 14, 1993·Science·R C Mulligan
Jun 1, 1996·Journal of Pediatric Surgery·G G MillerJ J Murphy
Aug 1, 1996·Respiration Physiology·M F YuM I Kotlikoff
Jan 1, 1997·Molecular Reproduction and Development·D A HumeM C Ostrowski

❮ Previous
Next ❯

Citations

May 2, 2002·The Anatomical Record·Munira XaymardanHans Zoellner
Mar 26, 2010·International Journal of Hematology·Makio OgawaDennis K Watson
Dec 26, 2001·Trends in Endocrinology and Metabolism : TEM·Ormond A MacDougald, Susanne Mandrup
Jun 14, 2008·Nature Reviews. Immunology·John A Hamilton
Mar 14, 2009·Nature Reviews. Immunology·Jeffrey W Pollard
Nov 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyan ChenXiaolin He
Dec 5, 2009·Critical Reviews in Food Science and Nutrition·Emily J McAllisterDavid B Allison
Jun 16, 2006·Inflammatory Bowel Diseases·Gisela PaulHans Herfarth
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·Max Lafontan
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Nov 9, 2005·The Journal of Clinical Investigation·Jacquelyn A ReedRandy J Seeley
Dec 8, 2011·Journal of Biomedical Science·Hailan LiDong-Seok Kim
Apr 23, 2010·Journal of Lipid Research·Florence MassieraGérard Ailhaud
Mar 21, 2001·Pharmacogenomics·Y D HalvorsenM R Briggs
Mar 26, 2013·Journal of Clinical Biochemistry and Nutrition·Rieko YachiChikako Kiyose
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Iordanes KaragiannidesCharalabos Pothoulakis
Sep 12, 2014·Journal of Physiological Anthropology·Hiroyuki SagayamaYasuki Higaki
Nov 6, 2002·Journal of Biomedical Materials Research·Cyril DésévauxChristiane Girard
Apr 24, 2010·Experimental Hematology·Makio OgawaDennis K Watson
Jul 7, 2009·Experimental Hematology·Yasuhiko SeraMakio Ogawa
Nov 26, 2008·Experimental Cell Research·Michelle N YarmoAlexander Sorisky
Sep 6, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tomonori KishinoTakashi Watanabe
Mar 11, 2008·Metabolism: Clinical and Experimental·Vanessa A ConstantAlexander Sorisky
Aug 8, 2007·Trends in Immunology·A SchäfflerB Salzberger
Apr 7, 2005·International Journal of Experimental Pathology·Hiroaki KimuraPatrizio Caturegli
Jul 21, 2009·Cell Proliferation·J LeeD Park
May 8, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Paulo W PiresAnne M Dorrance
Nov 3, 2004·Annales de chirurgie plastique et esthétique·L CasteillaJ P Chavoin
Jan 28, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·L LionettiA Barletta
Jul 25, 2006·Comptes rendus biologies·Gérard Ailhaud
Dec 13, 2005·Current Opinion in Immunology·Violeta Chitu, E Richard Stanley
May 22, 2013·Biochimica Et Biophysica Acta·Yun-Hee LeeJames G Granneman
Jun 30, 2016·Stem Cells·Carolina SerenaSonia Fernández-Veledo
Jan 26, 2012·The Journal of Infectious Diseases·Ha-Na Na, Jae-Hwan Nam
Jan 27, 2007·Molecular & Cellular Proteomics : MCP·Gloria Alvarez-LlamasRoel J Vonk
Oct 8, 2004·Gene Therapy·J FradetteJ C Glorioso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.