Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians

Cytokine
Alessandro P DelitalaFrancesco Cucca

Abstract

Cytokines release by adipocytes could interact with TSH secretion. We evaluated the relationship between adipocytokines and TSH. We further tested for association of cytokines and thyroid autoimmunity. We conducted a cross-sectional study in a community-based sample including 5385 individuals (2964 female) with TSH within the reference range. Subjects who reported taking thyroid medications or drugs that alter thyroid function were excluded. TSH, FT4, adiponectin, leptin, antibody against thyroperoxidase and against thyroglobulin were measured. Linear and logistic regression models were used to test for association. Females had higher adiponectin and leptin level and increased frequency of thyroid antibodies. In multiple regression analysis TSH was directly associated with leptin (β = 0.003, p = 0.001) and the presence of circulating antibody against thyroperoxidase (β = 0.315, p < 0.001), but negatively associated with age (β = -0.012, p < 0.001) and FT4 (β = -0.359, p < 0.001). Adiponectin, the presence of antibody against thyroglobulin and smoking habit were not associated with TSH levels (p = 0.223, p = 0.174 and p = 0.788, respectively). Logistic regression analysis revealed that higher adiponectin levels were associated w...Continue Reading

Citations

Jun 4, 2019·Journal of Clinical Medicine·Alessandro P DelitalaFrancesco Cucca
Feb 23, 2020·Journal of Clinical Medicine·Alessandro P DelitalaGiuseppe Fanciulli
Apr 10, 2020·Journal of Clinical Medicine·Alessandro P DelitalaCarlo Doria
Dec 21, 2018·Archives of Gynecology and Obstetrics·Alessandro P DelitalaGiuseppe Delitala
Jan 28, 2021·Journal of Clinical Medicine·Alessandro P DelitalaFrancesco Cucca
Jan 1, 2021·International Journal of Endocrinology·Agnieszka Baranowska-Bik, Wojciech Bik

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