PMID: 20648430Jul 22, 2010Paper

Adipocytokines and blood pressure, lipids and glucose metabolism in hypertensive perimenopausal women

Kardiologia polska
Agnieszka OlszaneckaDanuta Fedak

Abstract

The relationship between menopause and hypertension has been a topic of investigation for several years. In the pathogenesis of hypertension after menopause, metabolic disturbances play an important role. To assess the relationship between adipocytokines and blood pressure, lipid and glucose metabolism in middle-aged perimenopausal women with essential hypertension. The study included 192 women aged 40 to 60 years (mean age 51.73 +/- 1.82 years), 152 with mild and moderate essential hypertension and 40 normotensive age-matched controls. The diagnosis of menopause was based on the data from medical records and confirmed by serum concentrations of the FSH. The study population was stratified according to the menopausal status into four subgroups (normotensive pre- and postmenopausal, and hypertensive pre- and postmenopausal patients). In all subjects anthropometrical measurements and 24-hour ambulatory blood pressure monitoring were performed. Serum levels of leptin, adiponectin and resistin were measured using immunochemical assays. Fasting blood samples were taken for glucose, insulin and serum lipids concentration. Postmenopausal women did not differ from premenopausal in respect to mean arterial pressure (normotensive 85.2 +/...Continue Reading

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