Adipocytokines and liver fibrosis stages in patients with chronic hepatitis B virus infection

Hepatology International
Ching-Sheng HsuJia-Horng Kao

Abstract

Adipocytokines play an important role in lipid metabolism and liver disease progression. However, the interactions between hepatitis B virus (HBV) infection and adipocytokines remain largely unknown. To investigate the association of HBV infection with adipocytokines in HBV-infected and noninfected subjects. In addition, the impact of adipocytokines on serum HBV DNA, HBsAg levels and liver fibrosis stage was also examined. A case-control analysis of patients with and without chronic HBV infection was performed. The HBV group consisted of 187 patients with chronic HBV infection, and the control group consisted of 184 age-, gender- and body mass index-matched subjects without HBV infection. Fasting blood glucose, lipid profiles, adiponectin, leptin and visfatin levels were compared between the two groups. APRI and FIB-4 were calculated to estimate the severity of liver fibrosis. Most of the enrolled subjects had lower ALT levels [228 (57.7%) ALT < ULN] and milder hepatic fibrosis [381 (96.5%) APRI < 0.7; 307 (77.7%) FIB4 < 1.45]. The HBV group had significantly higher serum adiponectin and visfatin but lower leptin levels than the control group. This difference remained significant after adjustment for age, sex, BMI and ALT level...Continue Reading

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Citations

Nov 21, 2019·Alimentary Pharmacology & Therapeutics·Chia-Chi WangJia-Horng Kao
Nov 6, 2018·World Journal of Hepatology·Wanvisa UdomsinprasertYong Poovorawan
Aug 29, 2019·Frontiers in Endocrinology·Laszlo Otvos
Jan 7, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Jianbin ZhangJiangao Fan
Mar 25, 2017·Metabolic Syndrome and Related Disorders·Danica SrdicGordana Dragovic
Nov 11, 2020·International Journal of Molecular Sciences·Ming-Ling ChangSien-Sing Yang
Jul 31, 2021·World Journal of Gastroenterology : WJG·Yi-Wen ShiJian-Gao Fan
Sep 21, 2021·Expert Opinion on Pharmacotherapy·Ching-Sheng Hsu, Jia-Horng Kao

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