Adipocytokines in Down's syndrome, an atheroma-free model: Role of adiponectin

Archives of Gerontology and Geriatrics
M M CorsiFederico Licastro

Abstract

Down's syndrome (DS) is the most frequent chromosomal aberration in men. Moreover DS is considered an atheroma-free model. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-alpha high sensitivity (hsTNF-alpha), leptin and adiponectin from non-demented DS subjects of three different age cohorts (2-14, 20-50 and above 60 years) and healthy controls were measured. No clinical and sub-clinical inflammation was apparent in DS patients. Plasma levels of hsTNF-alpha, IL-6 and leptin were higher in children than in adult and old DS subjects. Instead, serum levels of adiponectin were increased in older DS patients than in DS children and adults. High levels of circulating adiponectin might protect DS from clinical complications of atherosclerosis.

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Feb 24, 2007·Archives of Gerontology and Geriatrics·F LicastroM M Corsi

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Citations

Nov 26, 2010·Pediatrics·Nansi S BoghossianUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Jan 24, 2013·Immunity & Ageing : I & a·Elena VianelloMassimiliano Marco Corsi Romanelli
May 31, 2015·European Journal of Internal Medicine·Diego Real de AsuaCarmen Suarez
Aug 12, 2014·Research in Developmental Disabilities·Diego Real de AsuaCarmen Suarez
Jul 18, 2018·Current Opinion in Pediatrics·Paolo VersacciBruno Marino
Dec 30, 2014·Diabetes & Metabolism Journal·Diego Real de AsuaCarmen Suarez
Aug 21, 2013·Developmental Disabilities Research Reviews·Warren B Zigman
Dec 21, 2019·Journal of Intellectual Disability Research : JIDR·A Gutierrez-HervasA Marcos
Jul 10, 2020·The Journal of Clinical Hypertension·Emilia Roy-VallejoDiego Real de Asúa
Aug 24, 2019·Journal of Intellectual Disability Research : JIDR·E A PitchfordD A Ulrich
Nov 30, 2018·Journal of Intellectual Disability Research : JIDR·J ChenbhanichT Treadwell
Mar 7, 2021·Biomedicines·Manon MoreauNathalie Janel
Aug 5, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Sohier YahiaNanees Salem

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