Adipocytokines, inflammatory and oxidative stress markers of clinical relevance altered in young overweight/obese subjects

Clinical Biochemistry
Eduardo Ottobelli ChielleMaria Beatriz Moretto

Abstract

The aim of the study was to assess the influence of overweight and obesity in youth on adipocytokines levels, inflammatory and oxidative markers. Cross-sectional study of 149 young adults (54 normal weight, 27 overweight, 68 obese).Clinical and biochemical parameters, including lipid profile, fasting glucose, insulin and HOMA were determined. The levels of adipocytokines(adiponectin, retinol-binding protein 4 (RBP4), and resistin), markers of inflammation (high-sensitivity C-reactive protein (hs-CRP) adenosine deaminase (ADA), dipeptidyl peptidase-IV (DPP-IV) activities, serum IL-6 levels and oxidative stress (malondialdehyde and ferric reducing antioxidant power - FRAP) were measured. Obese subjects presented significantly lower levels of Sulfhydryl groups (SH groups), adiponectin, HDL-C and the highest levels of RBP4, hs-CRP, resistin, IL-6, ADA, DPP-IV activities, and oxidative markers than compared to those who were of normal weight. There was a positive correlation between hs-CRP, IL-6, DDP-IV activity, anthropometric measurements and biochemical parameters. This analysis shows that resistin, RBP4, IL-6, ADA and DPP-IV activities and the reduction of adiponectin can promote inflammation, impairment of insulin sensitivity, ...Continue Reading

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Citations

Apr 2, 2016·Oxidative Medicine and Cellular Longevity·K S Petersen, C Smith
Jan 14, 2017·Pediatric Research·Jenni RosendahlSture Andersson
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Jun 1, 2018·The Journal of Clinical Endocrinology and Metabolism·Rasmus StenlidAnders Forslund
Nov 28, 2019·Oxidative Medicine and Cellular Longevity·Elena MorettiDaniela Cerretani

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