PMID: 3771091Jan 1, 1986Paper

Adipogenic activity in human plasma. Effects of feeding state and obesity

International Journal of Obesity
G SypniewskaP Björntorp

Abstract

The potential of plasma from obese and non-obese subjects to stimulate the formation of new adipocytes was studied by assays in rat adipose precursor cells in primary culture. Adipogenic activity was followed in terms of rate of lipid filling, analysed by determination of triglyceride contents per unit protein, stimulation of multiplication, measured as rate of incorporation of labelled thymidine into DNA, and stimulation of differentiation, followed as an increase in glycerophosphate dehydrogenase activity. Plasma from obese subjects contained an excess of activity stimulating lipid filling, closely associated to the recent body weight histories with increased activity with a recent increase of body weight and vice versa. There was also a strong association with plasma concentration of triglyceride. The importance of the latter was demonstrated by acute feeding experiments with triglyceride, as well as by addition of isolated very-low-density lipoprotein and chylomicron fractions which caused increases of lipid filling activity closely in parallel to triglyceride contents of the culture medium. Specific stimulatory properties of plasma from weight-increasing obese subjects on adipose precursor cell multiplication and different...Continue Reading

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