Adipokine, adropin and endothelin-1 levels in intrauterine growth restricted neonates and their mothers

Journal of Perinatal Medicine
Halil Ibrahim AydinSuleyman Kalman

Abstract

Intrauterine growth retardation/restriction (IUGR) is associated with fetal malnutrition. It has consequences for later life including increased incidence of obesity, diabetes mellitus, cardiovascular disease (CVD), and metabolic syndrome. Adipokines (adiponectin and leptin), adropin, and endothelin-1 are associated with obesity and metabolic syndrome regulation. Intrauterine changes in these mediators could affect programming of later adult obesity and metabolic syndrome. Our objectives were to compare the levels of these mediators in both cord and maternal blood between IUGR pregnancies and control, healthy pregnancies, and to study the correlation of adipokines with adropin and endothelin-1 in maternal and cord blood in IUGR pregnancies as well as in healthy control pregnancies. Maternal and cord blood samples were taken from 16 women with IUGR pregnancies and 16 women with healthy pregnancies. Serum levels of leptin, adiponectin, adropin, and endothelin-1 were measured by ELISA. Maternal blood adropin levels were significantly lower in the IUGR group than in the control group; the other mediators did not differ significantly. There was a positive correlation between maternal blood adropin and endothelin levels. (r=0.731, P=...Continue Reading

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Citations

Jul 5, 2017·Journal of Perinatal Medicine·Burcu Dincgez CakmakYasin Altekin
Nov 22, 2017·Journal of Cellular and Molecular Medicine·Antonio Pérez-PérezVíctor Sánchez-Margalet
Oct 20, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·R ZemetS Mazaki-Tovi
Aug 29, 2016·Hormone Molecular Biology and Clinical Investigation·Jorge R Pasqualini, Gérard S Chetrite
Mar 4, 2019·European Journal of Pediatrics·Eita Goto

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Methods Mentioned

BETA
enzyme-linked immunoassay
ELISA

Software Mentioned

Statistical Package for the Social Sciences

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