Adipokines and Cysteinyl Leukotrienes in the Pathogenesis of Asthma

Journal of Allergy
Michael J CoffeyPeter Mancuso

Abstract

Background. The prevalence of obesity has increased dramatically over the last decades, and its association with asthma is being increasingly recognized. Aims. Our hypothesis is that increased leptin and decreased adiponectin levels in obese subjects play a direct role in regulating inflammation in asthmatics. We wanted to examine the hypothesis that cysteinyl leukotrienes (cys-LT), inflammatory mediators that are regulated by adipokines, are involved in the pathogenesis of asthma. Methods. We studied a population of asthmatics and nonasthmatics, who in turn were divided into obese and nonobese categories. We examined leptin and its ratio to adiponectin, in asthmatics and nonasthmatics, with and without obesity. In addition, we measured cys-LT levels in exhaled breath condensate (EBC) and in peripheral blood monocytes (PBM) in these groups. Results. Leptin levels were increased in obese asthmatics compared to obese nonasthmatics. The leptin/adiponectin (L/A) ratio was higher in obese asthmatics compared to obese nonasthmatics. EBC cys-LT levels were elevated in asthmatics compared to nonasthmatics. Discussion. Proinflammatory adipokines, released from adipose tissue, may promote an asthma phenotype through enhanced cys-LT produ...Continue Reading

References

Oct 31, 1998·Nature·J M Friedman, J L Halaas
Nov 26, 1999·Archives of Internal Medicine·C A CamargoF E Speizer
May 3, 2000·Journal of Internal Medicine·L HellströmP Arner
Jun 9, 2000·Annual Review of Physiology·R S Ahima, J S Flier
Oct 12, 2000·The European Respiratory Journal·F MitsunobuM Harada
Mar 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·O AbrahamsenM Schlaak
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter MancusoGary B Huffnagle
Apr 10, 2002·The Journal of Allergy and Clinical Immunology·Paolo Montuschi, Peter J Barnes
Jul 12, 2002·The Journal of Allergy and Clinical Immunology·John Hunt
Jan 9, 2003·JAMA : the Journal of the American Medical Association·Kevin R FontaineDavid B Allison
Jan 23, 2004·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Mordechai YiglaDan Harlev
Feb 10, 2004·The Journal of Allergy and Clinical Immunology·Stefania ZanconatoEugenio Baraldi
May 18, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Peter MancusoMarc Peters-Golden
Oct 14, 2004·The Journal of Allergy and Clinical Immunology·Chiara MondinoPaolo Montuschi
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Stephanie A ShoreRichard A Johnston
Mar 2, 2006·The European Respiratory Journal·M Peters-GoldenJ M Edelman
Aug 8, 2006·The Journal of Allergy and Clinical Immunology·Stephanie A ShoreChristopher Hug
Jan 20, 2007·American Journal of Respiratory and Critical Care Medicine·David A Beuther, E Rand Sutherland
Jul 19, 2008·American Journal of Respiratory and Critical Care Medicine·E Rand SutherlandDonald Y M Leung
Dec 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Carlo PergolaOliver Werz
Jan 27, 2009·American Journal of Respiratory Cell and Molecular Biology·Benjamin D MedoffAndrew D Luster
Sep 11, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Tim J T SutherlandRobert J Hancox
Feb 20, 2010·Allergy and Asthma Proceedings·E Rand SutherlandDavid A Stempel
Sep 10, 2010·European Journal of Clinical Investigation·Paschalina GioulekaStelios Loukides
Nov 3, 2010·Respiratory Research·Foteini MalliZoe Daniil
Feb 22, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Fernando HolguinAnne M Fitzpatrick
Jun 23, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Carlo PergolaOliver Werz
Jan 19, 2012·JAMA : the Journal of the American Medical Association·Katherine M FlegalCynthia L Ogden
Mar 27, 2012·Biochimie·Nour Ali Assad, Akshay Sood
Jul 10, 2012·American Journal of Respiratory and Critical Care Medicine·Njira L LugogoMonica Kraft
Jul 28, 2012·American Journal of Respiratory and Critical Care Medicine·Olga SidelevaAnne E Dixon
Dec 25, 2012·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Agori TsarouchaKonstantinos I Gourgoulianis
Apr 18, 2013·American Journal of Respiratory and Critical Care Medicine·Dhananjay DesaiChris E Brightling
Jun 28, 2013·Annals of the American Thoracic Society·Akshay SoodDavid R Jacobs
Aug 3, 2013·American Journal of Respiratory and Critical Care Medicine·Nour AssadAkshay Sood

❮ Previous
Next ❯

Citations

Jan 25, 2017·Pulmonary Pharmacology & Therapeutics·Andrea BiancoAurora Daniele
May 4, 2017·The European Respiratory Journal·Thaw D HtetAnju E Joham
Dec 7, 2018·Journal of Applied Physiology·Aline Grandi SilvaCelso R F Carvalho

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Andréa LessardLouis-Philippe Boulet
Current Opinion in Allergy and Clinical Immunology
Marco FaillaCarlo Vancheri
© 2022 Meta ULC. All rights reserved