Adipokines and Endotoxemia Correlate with Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease (NAFLD)

Nutrients
Anika NierJörn M Schattenberg

Abstract

(1) Background: The etiology of non-alcoholic fatty liver disease (NAFLD) is multifactorial. Dietary composition has been implicated as a factor modulating intestinal barrier and could affect disease severity. The aim of this study was to evaluate dietary intake and markers of intestinal permeability in patients with NAFLD. (2) Methods: We enrolled 63 patients with NAFLD and compared them to age-matched controls. (3) Results: body mass index (BMI) and leptin to adiponectin ratio-the latter being an indicator of abdominal fat accumulation-correlated with the degree of hepatic steatosis being accompanied with rising levels of fasting insulin. Furthermore, endotoxin plasma levels and markers of inflammation were significantly higher in NAFLD compared to controls and increased with the severity of hepatic steatosis. Despite comparable intake of total energy and macronutrients, intake of fiber was lower in all patients with NAFLD compared to controls and were negatively related to disease severity. (4) Conclusions: Taken together, results of the present study suggest that fiber intake in patients is negatively related to steatosis degree and bacterial endotoxin levels, further suggesting that dietary fiber intake may be a target in ...Continue Reading

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Citations

Jun 20, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Isabel Gómez-HurtadoRubén Francés
Aug 23, 2020·International Journal of Molecular Sciences·Daniela Maria TanaseMariana Floria
Sep 10, 2021·Scientific Reports·Anja BaumannIna Bergheim
Nov 5, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Lingxuan AnFlorian Kühn

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Methods Mentioned

BETA
ELISA
biopsy

Clinical Trials Mentioned

NCT02366052
NCT03482284

Software Mentioned

GraphPad
GraphPad Prism

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