Adipokines and inflammation: is it a question of weight?

British Journal of Pharmacology
Vera FranciscoOreste Gualillo

Abstract

Obesity has reached epidemic proportions in the Western society and is increasing in the developing world. It is considered as one of the major contributors to the global burden of disability and chronic diseases, including autoimmune, inflammatory and degenerative diseases. Research conducted on obesity and its complications over the last two decades has transformed the outdated concept of white adipose tissue (WAT) merely serving as an energy depot. WAT is now recognized as an active and inflammatory organ capable of producing a wide variety of factors known as adipokines. These molecules participate through endocrine, paracrine, autocrine or juxtacrine crosstalk mechanisms in a great variety of physiological or pathophysiological processes, regulating food intake, insulin sensitivity, immunity and inflammation. Although initially restricted to metabolic activities (regulation of glucose and lipid metabolism), adipokines currently represent a new family of proteins that can be considered key players in the complex network of soluble mediators involved in the pathophysiology of immune/inflammatory diseases. However, the complexity of the adipokine network in the pathogenesis and progression of inflammatory diseases has posed, ...Continue Reading

References

Feb 17, 2000·Cellular Immunology·C Martín-RomeroV Sánchez-Margalet
Sep 11, 2001·Biochemical and Biophysical Research Communications·Y FigenschauB Sveinbjörnsson
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathalie BussoCem Gabay
Sep 26, 2006·Nature Reviews. Immunology·Herbert Tilg, Alexander R Moschen
Jul 10, 2008·Scandinavian Journal of Rheumatology·S-W LeeS-K Lee
Feb 12, 2009·Cardiovascular Therapeutics·Yiyi SunYitao Wang
Jul 1, 2009·Arthritis and Rheumatism·Young Hee RhoC Michael Stein
Feb 4, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jian Q FengChuan-Ju Liu
Jun 11, 2010·Arthritis Research & Therapy·Stéphane PalluNathalie Presle
Dec 9, 2010·Rheumatology International·Shereen M OlamaMohammed Elarman
Jan 5, 2011·Arthritis Research & Therapy·Eun Ha KangYeong Wook Song
Mar 19, 2011·The Journal of Nutritional Biochemistry·Seung-Jin KimTaesun Park
May 31, 2011·Annals of the Rheumatic Diseases·Rodolfo GómezOreste Gualillo
Oct 20, 2011·Pharmacology & Therapeutics·Chuan-ju Liu, Xavier Bosch
Mar 7, 2012·Arthritis and Rheumatism·Richard F LoeserMary B Goldring
Jul 27, 2012·Arthritis and Rheumatism·Jun DengLiwei Lu
Aug 23, 2012·Cytokine & Growth Factor Reviews·Xiuping ChenYitao Wang
Jan 24, 2013·Therapeutic Advances in Chronic Disease·Evan Meszaros, Charles J Malemud
Apr 13, 2013·Frontiers of Medicine·Yingjiang Zhou, Liangyou Rui
May 3, 2013·European Journal of Medical Research·Ebtesam A Al-Suhaimi, Adeeb Shehzad
May 28, 2013·In Vitro Cellular & Developmental Biology. Animal·Simone Coghetto AcedoAlessandra Gambero
Jun 19, 2013·BMC Pulmonary Medicine·Milena Baptistella GrottaEdson Antunes
Aug 3, 2013·Drug Discovery Today·Morena ScoteceOreste Gualillo
Oct 24, 2013·Frontiers in Immunology·Claudio ProcacciniGiuseppe Matarese
Nov 26, 2013·European Journal of Immunology·Pedro M M Moraes-VieiraNiels O S Câmara
Jan 15, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Meilian Liu, Feng Liu
Jan 21, 2014·Autoimmunity·Abdullah Alghasham, Zafar Rasheed
May 8, 2014·Clinical and Experimental Immunology·G TianD Zhou
Jul 19, 2014·World Journal of Orthopedics·Thitiya Poonpet, Sittisak Honsawek
Jul 31, 2014·Cellular Microbiology·Victoria J Vieira-Potter
Sep 18, 2014·The Journal of Endocrinology·Mark A ExleyLydia Lynch
Oct 12, 2014·Metabolism: Clinical and Experimental·Heike Münzberg, Christopher D Morrison
Mar 10, 2015·Lancet·S Glyn-JonesA J Carr
Mar 27, 2015·Clinical and Experimental Immunology·E BrotfainR Levy

❮ Previous
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Citations

Feb 12, 2019·Scientific Reports·Blanca Grases-PintóÀngels Franch
Mar 21, 2019·Annals of the New York Academy of Sciences·Lidi LiuHui B Sun
Jan 19, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Xin YuanXiaohong Yang
Aug 10, 2019·Current Medical Research and Opinion·Addolorata CorradoFrancesco Paolo Cantatore
Dec 10, 2019·Current Opinion in Lipidology·Geneviève TavernierNathalie Viguerie
Nov 18, 2019·Endocrine Regulations·Daniel AddaiAnna Tolekova
Apr 28, 2019·International Journal of Molecular Sciences·Clara Ruiz-FernándezOreste Gualillo
Jul 9, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Paulina ŻelechowskaElżbieta Kozłowska
Jun 18, 2020·International Journal of Molecular Sciences·Kelvin Ka-Lok WuKenneth King-Yip Cheng
Jun 11, 2020·Current Obesity Reports·Paul WeiheSusann Weihrauch-Blüher
Feb 1, 2019·Journal of Thrombosis and Thrombolysis·Armando TripodiFlora Peyvandi
Jan 17, 2019·International Journal of Molecular Sciences·Rachael Eugenie TarlintonSvetlana Khaiboullina
Apr 30, 2020·Nutrients·María Dolores Ordóñez-DíazJuan Luis Pérez-Navero
Apr 8, 2020·Clinical Epigenetics·Carolina SerenaSonia Fernández-Veledo
Sep 10, 2020·Journal of Clinical Medicine·Andrzej Kazimierz JaworekMieczysław Pokorski
May 8, 2020·Nutrients·Iwona KojtaAgnieszka Błachnio-Zabielska
Aug 15, 2020·Frontiers in Immunology·Geoffroy MéryAudrey Le Gouellec
Dec 2, 2020·International Journal of Molecular Sciences·Patricia Ramos-RamírezApostolos Bossios
Dec 3, 2020·International Journal of Molecular Sciences·Dóra KovácsDániel Törőcsik
Aug 3, 2019·European Journal of Medicinal Chemistry·Lucia BiasuttoMario Zoratti
Dec 4, 2020·Aging and Disease·Alexey MoskalevCalogero Caruso
Mar 27, 2019·Biochemical Pharmacology·Vera FranciscoOreste Gualillo
Nov 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tahereh FarkhondehSaeed Samarghandian
May 1, 2021·Nature Reviews. Immunology·Kristin DePeaux, Greg M Delgoffe
May 4, 2021·Frontiers in Cell and Developmental Biology·Jing XuDaisuke Koya
May 14, 2021·International Journal of Immunopathology and Pharmacology·Liberato GiardulloFrancesco Paolo Cantatore
May 15, 2021·Seminars in Cancer Biology·Nikolaos SpyrouMaria Dalamaga
May 18, 2021·Frontiers in Endocrinology·Maria Alessandra Gammone, Nicolantonio D'Orazio
Jun 5, 2021·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Hassan GhobadiMohammad Reza Aslani
Aug 8, 2021·Immunological Medicine·Haruka Tsuchiya, Keishi Fujio
Aug 17, 2021·Stem Cells Translational Medicine·Angela Palumbo PiccionelloMichele Riccio

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