Adipokines and inflammatory markers in elderly subjects with high risk of type 2 diabetes and cardiovascular disease

Scientific Reports
Tuula SaukkonenSirkka Keinänen-Kiukaanniemi

Abstract

Inflammation plays a significant role in pathogenesis of diabetes and atherosclerosis. Increased adiposity with an upregulation of cytokines in prediabetes has been associated with vascular inflammation and considered a leading causal factor for type 2 diabetes (T2D). Information on adipokines and inflammatory markers in prediabetes, defined by hemoglobin A1C (HbA1c) 5.7-6.4% in addition to impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), are sparse. We conducted a population-based cross-sectional study (part of a follow-up study) of inhabitants of Oulu, Finland, born in 1935. Inflammatory markers and traditional risk markers of 367 subjects were measured. The glucose status was determined by an oral glucose tolerance test (OGTT) and HbA1c. Inflammatory markers and glycemic levels were analysed using analysis of covariance (ANCOVA). Of the participants, 193 were normoglycemic, 82 had prediabetes and 40 T2D. Inflammatory cytokines were significantly higher in subjects with prediabetes as compared to normoglycemic subjects: IL-4 (14.9 vs 5.9 pg/ml, p = 0.041), IP-10 (251 vs 209 pg/ml, p = 0.05), TNF-α (10.4 vs 6.9 pg/ml, p = 0.027), RANTES (43.3 vs 33.1 pg/ml, p = 0.009), CD40L (3708 vs 1671 pg/ml, p = 0.010) ...Continue Reading

References

Aug 13, 2003·Circulation·Nerea VaroUwe Schönbeck
Nov 9, 1957·British Medical Journal·J REIDM M ANDREWS
Jan 6, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·G S Hotamisligil
Mar 11, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·M Crook
May 18, 2004·Endocrine·Stephen E Borst
Sep 8, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Birgit GustafsonUlf Smith
Oct 4, 2007·The Journal of Clinical Endocrinology and Metabolism·Christian HerderStephan Martin
Mar 8, 2008·Annals of Clinical Biochemistry·Bendix CarstensenUNKNOWN DPS Study Group
Apr 5, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Vincent BraunersreutherFrançois Mach
Jul 17, 2008·Archives of Physiology and Biochemistry·Iria Nieto-VazquezMargarita Lorenzo
Aug 2, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Pål AukrustJan K Damås
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Jul 9, 2011·The British Journal of Nutrition·Mari C W MyhrstadStine M Ulven
Aug 19, 2011·Neurology·F Canouï-PoitrineUNKNOWN PRIME Study Group
Mar 30, 2013·The Journal of Clinical Endocrinology and Metabolism·Sang Ah LeeDae Ho Lee
Nov 11, 2015·Nature Reviews. Endocrinology·Denise E Lackey, Jerrold M Olefsky
Jan 11, 2016·Aging Clinical and Experimental Research·Hannamari LinnaMarkku Timonen
May 12, 2016·Genetic Testing and Molecular Biomarkers·Zhouqing HuangWeijian Huang
Jul 22, 2016·Diabetes Care·Rena M PollackGil Leibowitz
Jan 1, 2014·Diabetology International·Graham Rena, Kei Sakamoto

❮ Previous
Next ❯

Citations

Mar 3, 2019·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Apr 2, 2020·The American Journal of Clinical Nutrition·Saranya PalaniswamyMarjo-Riitta Järvelin
Aug 14, 2019·American Journal of Physiology. Endocrinology and Metabolism·Francesca SchinzariCarmine Cardillo
Jun 25, 2020·Cadernos de saúde pública·Maylla Luanna Barbosa Martins BragançaAntônio Augusto Moura da Silva
Jan 19, 2021·Journal of Diabetes Investigation·Yingshan LiuLingling Xu
Jan 20, 2021·Diabetes/metabolism Research and Reviews·Jessica R WeaverJung Bok Lee
Apr 4, 2021·Journal of Clinical Medicine·Kari A MäkeläKarl-Heinz Herzig
Jun 1, 2021·Frontiers in Immunology·Xiongfeng PanAizhong Liu
Aug 10, 2021·Current Oral Health Reports·Carina M Silva-Boghossian, Romulo S Dezonne
Sep 22, 2021·Experimental Gerontology·Israel S RibeiroRobson A A Silva

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

SAS
R package “ corrplot ”

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Related Papers

European Journal of Clinical Investigation
F SoriguerG Olveira-Fuster
European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Peter ManuMarc De Hert
Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Jun-Hui XieXue-Feng Yu
© 2022 Meta ULC. All rights reserved