Nov 15, 2008

Adipokines and insulin resistance

Molecular Medicine
Katja RabeUli C Broedl

Abstract

Obesity is associated with an array of health problems in adult and pediatric populations. Understanding the pathogenesis of obesity and its metabolic sequelae has advanced rapidly over the past decades. Adipose tissue represents an active endocrine organ that, in addition to regulating fat mass and nutrient homeostasis, releases a large number of bioactive mediators (adipokines) that signal to organs of metabolic importance including brain, liver, skeletal muscle, and the immune system--thereby modulating hemostasis, blood pressure, lipid and glucose metabolism, inflammation, and atherosclerosis. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones adiponectin, chemerin, leptin, omentin, resistin, retinol binding protein 4, tumor necrosis factor-alpha and interleukin-6, vaspin, and visfatin on insulin resistance.

  • References182
  • Citations200

Citations

Mentioned in this Paper

Metabolic Process, Cellular
Pathogenic Aspects
Immune System
Insulin Sensitivity
SERPINA12
Adiponectin
Pathogenesis
Tumor Necrosis Factor-alpha
ADIPOQ gene
NAMPT gene

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