Adipokines and the Right Ventricle: The MESA-RV Study

PloS One
Michael O HarhaySteven M Kawut

Abstract

Obesity is associated with changes in both right (RV) and left (LV) ventricular morphology, but the biological basis of this finding is not well established. We examined whether adipokine levels were associated with RV morphology and function in a population-based multiethnic sample free of clinical cardiovascular disease. We examined relationships of leptin, resistin, TNF-α, and adiponectin with RV morphology and function (from cardiac MRI) in participants (n = 1,267) free of clinical cardiovascular disease from the Multi-Ethnic Study of Atherosclerosis (MESA)-RV study. Multivariable regressions (linear, quantile [25th and 75th] and generalized additive models [GAM]) were used to examine the independent association of each adipokine with RV mass, RV end-diastolic volume (RVEDV), RV end-systolic volume (RVESV), RV stroke volume (RVSV) and RV ejection fraction (RVEF). Higher leptin levels were associated with significantly lower levels of RV mass, RVEDV, RVESV and stroke volume, but not RVEF, after adjustment for age, gender, race, height and weight. These associations were somewhat attenuated but still significant after adjustment for traditional risk factors and covariates, and were completely attenuated when correcting for th...Continue Reading

References

Jan 1, 1990·Epidemiology·K J Rothman
Jul 1, 1989·European Heart Journal·H ErikssonL Wilhelmsen
Oct 1, 1980·Biochemical Society Transactions·J Shepherd
Aug 2, 2002·The New England Journal of Medicine·Satish KenchaiahRamachandran S Vasan
Oct 25, 2002·American Journal of Epidemiology·Diane E BildRussell P Tracy
Jan 11, 2003·The American Journal of Cardiology·Peter G DaniasWarren J Manning
Jul 29, 2003·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Peter G DaniasWarren J Manning
Aug 2, 2003·Circulation Research·Venkatesh RajapurohitamMorris Karmazyn
May 14, 2005·Circulation Research·Anders H Berg, Philipp E Scherer
May 23, 2006·AJR. American Journal of Roentgenology·Shunsuke NatoriDavid A Bluemke
Dec 5, 2006·Cardiovascular Research·Teresa A HopkinsKenneth Walsh
Nov 17, 2007·Cardiovascular Research·Kenneth R McGaffinChristopher P O'Donnell
Apr 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Michaela KozakovaEle Ferrannini
Aug 8, 2009·The American Journal of Cardiology·Wolfgang LiebRamachandran S Vasan
Aug 15, 2009·Journal of the American College of Cardiology·Oliver J RiderStefan Neubauer
Dec 17, 2009·European Journal of Endocrinology·Stefan GustafssonErik Ingelsson
Mar 13, 2010·JACC. Cardiovascular Imaging·Evrim B TurkbeyDavid A Bluemke
Jan 22, 2011·Nature Reviews. Immunology·Noriyuki OuchiKenneth Walsh
Aug 16, 2011·Circulation. Heart Failure·Aurelian BidulescuGary H Gibbons
Jan 19, 2012·JAMA : the Journal of the American Medical Association·Katherine M FlegalCynthia L Ogden
May 29, 2013·The American Journal of Cardiology·Matthew A AllisonJoao A Lima
Jul 3, 2013·Journal of the American College of Cardiology·Hiram Beltrán-SánchezSean McElligott
Jul 23, 2013·Metabolism: Clinical and Experimental·Johan Van de VoordeKelly Decaluwé

❮ Previous
Next ❯

Citations

Jan 2, 2021·The American Journal of Cardiology·Koki NakanishiIssei Komuro

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
GAM

Software Mentioned

MESA
Windows
QMASS
STATA
Lung

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.