Adipokines are Associated With Hypertension in Metabolically Healthy Obese (MHO) Children and Adolescents: A Prospective Population-Based Cohort Study

Journal of Epidemiology
Wenqing DingJie Mi

Abstract

The potential mechanism underlying the relationship between the risk of cardiovascular diseases and metabolically healthy obese (MHO) individuals remains unclear. The aim of the study was to prospectively investigate the potential role of the adipokines in the association between the MHO phenotype and hypertension in children and adolescents. A total of 1184 participants at baseline were recruited from a cohort of the Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study. The participants were classified according to their body mass index (BMI) and metabolic syndrome (MS) components. The levels of the adipokines, including leptin, adiponectin, and resistin, were measured. MHO individuals had higher leptin levels (11.58 ug/L vs 1.20 ug/L), leptin/adiponectin ratio (1.18 vs 0.07), and lower adiponectin (11.65 ug/L vs 15.64 ug/L) levels compared to metabolically healthy normal-weight individuals (all P < 0.05). Compared to metabolically healthy normal-weight individuals, the prevalence of high leptin levels (26.5% vs 0.4%), low adiponectin levels (17.9% vs 6.3%) and a high leptin/adiponectin ratio (26.0% vs 2.1%) was higher in MHO individuals (all P < 0.01). The MHO individuals with abnormal adipokines were significantly m...Continue Reading

References

Jul 11, 2001·Obesity Research·Y W ParkD Gallagher
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Qing HeDympna Gallagher
Sep 16, 2003·Obesity Research·Kohtaro AsayamaMatsuo Taniyama
Jan 20, 2005·Journal of Internal Medicine·M E Trujillo, P E Scherer
Apr 15, 2006·Hormones : International Journal of Endocrinology and Metabolism·Antje KörnerWieland Kiess
May 27, 2006·Stroke; a Journal of Cerebral Circulation·Stefan PilzHarald Mangge
Nov 14, 2006·Lancet·Kun-Ho YoonHo-Young Son
Sep 14, 2007·Pediatric Diabetes·Paul ZimmetUNKNOWN IDF Consensus Group
Aug 13, 2008·Archives of Internal Medicine·Norbert StefanHans-Ulrich Häring
Oct 18, 2008·Journal of the American College of Cardiology·Seth S MartinMuredach P Reilly
May 29, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Rachel P Wildman
Sep 2, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B I ShandC M Frampton
Nov 6, 2010·Journal of Obesity·Jie MiKatherine Cianflone
Apr 18, 2012·The Journal of Clinical Endocrinology and Metabolism·Mark Hamer, Emmanuel Stamatakis
Oct 20, 2012·Journal of Hypertension·Seung Ku LeeChol Shin
May 3, 2013·Diabetes Care·Guy-Marino HinnouhoArchana Singh-Manoux
Aug 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Catherine M Phillips, Ivan J Perry
Dec 4, 2013·Annals of Internal Medicine·Caroline K KramerRavi Retnakaran
Feb 8, 2014·Nestlé Nutrition Institute Workshop Series·Anoop Misra, Swati Bhardwaj
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Norbert StefanMatthias B Schulze
Aug 28, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·T DuX Yu

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Citations

Jul 3, 2019·International Journal of Molecular Sciences·Antonina OrlandoSimonetta Genovesi
Sep 29, 2020·Hypertension·Mieczysław Litwin, Janusz Feber
May 11, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mieczysław Litwin, Zbigniew Kułaga
Jun 30, 2018·Molecular Medicine Reports·Bing LiuHaofu Wang
Jun 11, 2020·Revista da Associação Médica Brasileira·Vanessa S FontesAna Paula C Cândido
May 3, 2019·Endocrine Research·Rita A Gómez-DíazFernando Guerrero-Romero
Apr 10, 2021·European Journal of Pediatrics·Mariana De Santis FilgueirasJuliana Farias de Novaes

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
ELISA

Software Mentioned

SPSS

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