Adipokines, cytokines and body fat stores in hepatitis C virus liver steatosis

World Journal of Hepatology
Emilio González-ReimersFrancisco Santolaria-Fernández

Abstract

To identify patients with or without liver steatosis and its severity in treatment-naïve patients affected by hepatitis C virus (HCV) infection. We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body (by densitometry), hormones [insulin, homeostatic model assessment (HOMA)], adipokines (resistin, adiponectin, leptin), and cytokines (tumor necrosis factor α, interleukin-6). Although the intensity of liver steatosis is related to trunk fat mass and HOMA, 33% of patients showed no liver steatosis, and this finding was not related to body mass index or genotype. Besides trunk fat mass, no other factor was related to the presence or not of liver steatosis, or to the intensity of it, by multivariate analysis. Lean mass was not related to liver steatosis. Adiponectin levels were lower among patients. No differences were observed in leptin and resistin. Steatosis in HCV infection is common (67.2%), and closely related to trunk fat, and insulin resistance, but not with leg fat mass or adipokines.

References

Jul 25, 2000·Journal of Hepatology·R TestaT Barreca
Jul 25, 2000·Journal of Hepatology·L Rubbia-BrandtF Negro
Nov 30, 2000·The American Journal of Gastroenterology·E GianniniR Testa
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L E AdinolfiG Ruggiero
Jul 27, 2002·Digestive Diseases and Sciences·Javier CrespoFernando Pons-Romero
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexander MontoTeresa L Wright
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takayuki MasakiHironobu Yoshimatsu
Jan 13, 2005·The Journal of Clinical Endocrinology and Metabolism·Jean-Michel PetitPatrick Hillon
May 17, 2007·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Robert P MyersFrancoise Imbert-Bismut
Jun 21, 2007·American Journal of Physiology. Endocrinology and Metabolism·E MauryS M Brichard
Jun 29, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ian Homer Y CuaJacob George
Jul 26, 2007·Journal of Viral Hepatitis·D SiagrisC Labropoulou-Karatza
Oct 17, 2007·Annual Review of Physiology·Martin G MyersHeike Münzberg
May 1, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Muhammad Y SheikhArun J Sanyal
Mar 24, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Chao-Hung HungPei-Wei Wang
Apr 21, 2009·Gastroenterology·Jianhua WangJacob George
Oct 24, 2009·Annals of Nutrition & Metabolism·E González-ReimersF Valladares-Parrilla
Sep 14, 2012·Journal of Atherosclerosis and Thrombosis·Mitsuyoshi TakaharaTadashi Nakamura
Feb 13, 2014·American Journal of Physiology. Endocrinology and Metabolism·Mario BustamanteSonja Buvinic
Dec 31, 2014·World Journal of Gastroenterology : WJG·Ren-Nan FengChang-Hao Sun

❮ Previous
Next ❯

Citations

Dec 24, 2019·Expert Review of Gastroenterology & Hepatology·Vassilios A SevastianosSpyros P Dourakis
Dec 16, 2020·International Journal of Molecular Sciences·Maite Martínez-UñaMarta G Novelle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.