Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis

World Journal of Gastroenterology : WJG
Maria KalafateliVasiliki Nikolopoulou

Abstract

To investigate the adipokine levels of leptin, adiponectin, resistin, visfatin, retinol-binding protein 4 (RBP4), apelin in alcoholic liver cirrhosis (ALC). Forty non-diabetic ALC patients [median age: 59 years, males: 35 (87.5%), Child-Pugh (CP) score: median 7 (5-12), CP A/B/C: 18/10/12, Model for End-stage Liver Disease (MELD): median 10 (6-25), follow-up: median 32.5 mo (10-43)] were prospectively included. The serum adipokine levels were estimated in duplicate by ELISA. Somatometric characteristics were assessed with tetrapolar bioelectrical impedance analysis. Pearson's rank correlation coefficient was used to assess possible associations with adipokine levels. Univariate and multivariate Cox regression analysis was used to determine independent predictors for overall survival. Body mass index: median 25.9 (range: 20.1-39.3), fat: 23.4% (7.6-42.1), fat mass: 17.8 (5.49-45.4), free fat mass: 56.1 (39.6-74.4), total body water (TBW): 40.6 (29.8-58.8). Leptin and visfatin levels were positively associated with fat mass (P < 0.001/P = 0.027, respectively) and RBP4 with TBW (P = 0.025). Median adiponectin levels were significantly higher in CPC compared to CPA (CPA: 7.99 ± 14.07, CPB: 7.66 ± 3.48, CPC: 25.73 ± 26.8, P = 0.04),...Continue Reading

References

Sep 30, 1998·Gastroenterology·A J McCulloughS C Kalhan
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H HenriksenF Bendtsen
Jul 25, 2000·Journal of Hepatology·R TestaT Barreca
Nov 4, 2000·The American Journal of Clinical Nutrition·R J Kuczmarski, K M Flegal
Nov 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PirlichM Plauth
Jan 11, 2001·The American Journal of Gastroenterology·A UygunK Dagalp
Feb 24, 2001·Nature·C M SteppanM A Lazar
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hajime HondaNobuhiro Sato
Jul 20, 2002·Journal of Hepatology·Isabelle A LeclercqGraham R Robertson
Dec 31, 2002·Biochemical and Biophysical Research Communications·Lisa PatelStephen A Smith
Dec 23, 2003·The American Journal of Gastroenterology·Naga ChalasaniRobert V Considine
Jan 16, 2004·Gastroenterology·Yoshihiro KamadaYuji Matsuzawa
Mar 11, 2004·American Journal of Physiology. Endocrinology and Metabolism·Uwe J F TietgeMatthias J Bahr
Dec 4, 2004·PLoS Medicine·Michael LehrkeMitchell A Lazar
Dec 8, 2004·Journal of Hepatology·Paul AnguloMichael D Jensen
Jan 27, 2005·Alcohol·Anna Mae Diehl
Feb 16, 2006·American Journal of Physiology. Endocrinology and Metabolism·Matthias J BahrUwe J F Tietge
Jun 16, 2006·The New England Journal of Medicine·Timothy E GrahamBarbara B Kahn
Sep 6, 2006·The American Journal of Gastroenterology·Emmanuel TsochatzisAthanasios J Archimandritis
Dec 15, 2006·Nature·Jean-Pierre Després, Isabelle Lemieux
Jun 5, 2007·Clinics in Liver Disease·Andrew D CloustonElizabeth E Powell
Oct 17, 2007·Annual Review of Physiology·Martin G MyersHeike Münzberg
Jul 9, 2008·Scandinavian Journal of Gastroenterology·Emmanuel TsochatzisAthanasios J Archimandritis
Sep 26, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alessandro PrincipeWladimiro Jiménez
Nov 15, 2008·Molecular Medicine·Katja RabeUli C Broedl
Dec 11, 2008·Journal of Gastroenterology and Hepatology·Christa BuechlerClaus Hellerbrand
Dec 17, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jan Freark de BoerUwe J F Tietge
Feb 23, 2010·Seminars in Liver Disease·Alejandro FornerJordi Bruix
Sep 7, 2011·Digestive Diseases·Fabio MarraAngela Provenzano
Aug 29, 2012·Biochemical and Biophysical Research Communications·Yukio AritaYuji Matsuzawa
Sep 22, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David van der PoortenJacob George
Aug 1, 2013·World Journal of Gastroenterology : WJG·Zhi-Xia DongJian-Hua Wang
Feb 1, 2014·Lancet·Emmanuel A TsochatzisAndrew K Burroughs
Mar 19, 2014·Archives of Biochemistry and Biophysics·Erica NovoMaurizio Parola

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Citations

Mar 6, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shifang HuangLanfang Li
Oct 7, 2016·PloS One·Melissa A Fulham, Pranoti Mandrekar
Jul 1, 2017·International Journal of Molecular Sciences·Christa BuechlerCharalampos Aslanidis
Sep 21, 2017·Nature Reviews. Gastroenterology & Hepatology·Richard ParkerBin Gao
Apr 21, 2018·Arthritis & Rheumatology·Yoko YokoyamaSei-Ichiro Motegi
Nov 6, 2018·The Journal of Clinical Endocrinology and Metabolism·Maria Giovanna ScaraleClaudia Menzaghi
Jan 6, 2016·World Journal of Hepatology·Fernando Gomes Romeiro, Laís Augusti
Jan 18, 2018·Oncotarget·Shuang-Yu LvYan-Dong Wang
May 10, 2017·Frontiers in Pharmacology·Xinrui LvYan-Dong Wang
Jul 27, 2017·Clinical and Experimental Medicine·Sabrina KrautbauerChrista Buechler
Jun 9, 2016·World Journal of Gastroenterology : WJG·Raika JamaliMohammad Hossein Aarabi
Jul 29, 2020·International Journal of Molecular Sciences·Misaq HeydariCarmen Peralta
May 28, 2020·Experimental & Molecular Medicine·Young-Ri Shim, Won-Il Jeong
May 4, 2017·World Journal of Gastroenterology : WJG·Michał KuklaMarek Hartleb
Sep 25, 2021·Alcoholism, Clinical and Experimental Research·Thiyagarajan GopalViswanathan Saraswathi

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