Adiponectin: A Predictor for Breast Cancer Survival?

European Journal of Breast Health
Hikmet Erhan GüvenNeşe Ersöz Gülçelik

Abstract

Breast cancers in women with low serum adiponectin levels have been reported to show phenotypes that are more aggressive. In 2008, we investigated the relationship between serum adiponectin levels and breast cancer in our case-controlled study involving 83 patients, in which serum adiponectin levels were measured preoperatively. In this study, we aimed to investigate the relationship between serum adiponectin levels and breast cancer-specific survival among these 83 patients. All 83 patients with stage I-III breast cancer, whose adiponectin levels were measured preoperatively in 2008 were enrolled in this study. The patients had no history of medications influencing insulin resistance prior to collecting the blood samples. Serum adiponectin concentrations were measured after overnight fasting (≥12 hours) by drawing a venous blood sample of 30 mL from the arm. ELISA (B-Bridge Human Adiponectin ELISA kit) was used for testing. The mean adiponectin level was found to be 15,300 ng/mL. When the adiponectin levels of the patients were analyzed according to the stage of the disease, adiponectin levels tended to be significantly lower as the stage increased. The stage of the disease was an important determinant for both Diseas Free Sur...Continue Reading

Citations

Oct 28, 2019·International Journal of Environmental Research and Public Health·Katarzyna Tomaszek, Agnieszka Muchacka-Cymerman
Feb 17, 2021·Clinical & Experimental Metastasis·Sneha SoniChandi C Mandal
May 1, 2021·International Journal of Molecular Sciences·Francesca PiccottiMarta Truffi

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