Adiponectin abates diabetes-induced endothelial dysfunction by suppressing oxidative stress, adhesion molecules, and inflammation in type 2 diabetic mice.

American Journal of Physiology. Heart and Circulatory Physiology
Sewon LeeCuihua Zhang

Abstract

Adiponectin (APN) can confer protection against metabolism-related illnesses in organs such as fat, the liver, and skeletal muscle. However, it is unclear whether APN improves endothelial-dependent nitric oxide-mediated vasodilation in type 2 diabetes and, if so, by what mechanism. We tested whether exogenous APN delivery improves endothelial function in type 2 diabetic mice and explored the mechanisms underlying the observed improvement. To test the hypothesis, we injected adenovirus APN (Ad-APN) or adenovirus β-galactosidase (Ad-βgal; control virus) via the tail vein in control (m Lepr(db)) and diabetic (Lepr(db); db/db) mice and studied vascular function of the aorta ex vivo. Ad-APN improved endothelial-dependent vasodilation in db/db mice compared with Ad-βgal, whereas Ad-APN had no further improvement on endothelial function in control mice. This improvement was completely inhibited by a nitric oxide synthase inhibitor (N(G)-nitro-l-arginine methyl ester). Serum triglyceride and total cholesterol levels were increased in db/db mice, and Ad-APN significantly reduced triglyceride levels but not total cholesterol levels. Immunoblot results showed that interferon-γ, gp91(phox), and nitrotyrosine were markedly increased in the ...Continue Reading

References

Mar 1, 1996·Diabetes Care·D GiuglianoG Paolisso
Jun 1, 1997·The Journal of Clinical Investigation·S GuptaC Schindler
Mar 17, 2000·Circulation Research·K K GriendlingM Ushio-Fukai
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·K HottaY Matsuzawa
Aug 15, 2000·Journal of Cardiovascular Pharmacology·M J MihmJ A Bauer
Sep 23, 2000·Nature·A J Lusis
Dec 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·M C BourdillonJ L McGregor
Feb 19, 2002·Atherosclerosis·Kazuo KitagawaMasatsugu Hori
Jun 18, 2002·Nature Medicine·Norikazu MaedaYuji Matsuzawa
Jul 19, 2002·Cardiovascular Research·Tohru FukaiDavid G Harrison
Nov 2, 2002·Nature Medicine·Andrew C Li, Christopher K Glass
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Michio ShimabukuroYuji Matsuzawa
Jul 16, 2003·Hypertension·Noriyuki OuchiYuji Matsuzawa
Nov 19, 2003·Current Opinion in Lipidology·Noriyuki OuchiKenneth Walsh
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·K C B TanK S L Lam
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Apr 6, 2006·Clinical Endocrinology·Tiziana RontiElmo Mannarino
May 3, 2006·Hypertension·Koji OhashiIichiro Shimomura
Dec 5, 2006·Cardiovascular Research·Teresa A HopkinsKenneth Walsh
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Jul 27, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Martin M HartgeUlrich Kintscher
Nov 28, 2007·Annual Review of Pathology·Göran K HanssonCecilia Söderberg-Nauclér
May 20, 2008·Cardiovascular Research·Robert KleemannTeake Kooistra
May 31, 2008·Atherosclerosis·Ling TianYuchang Fu
Oct 14, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Xue GaoCuihua Zhang
Nov 26, 2008·Journal of Molecular and Cellular Cardiology·Yu CaoXin L Ma
Jan 3, 2009·Clinical Science·Hanrui ZhangCuihua Zhang
Mar 25, 2009·Antioxidants & Redox Signaling·Vincent JaquetJ David Lambeth
May 30, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Hanrui ZhangCuihua Zhang
Apr 8, 2010·European Journal of Pharmacology·Zahra Fatehi-HassanabadBrian L Furman
Jun 29, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Xiuping ChenCuihua Zhang
Oct 26, 2010·Basic Research in Cardiology·Yoonjung ParkCuihua Zhang
Feb 3, 2011·World Journal of Cardiology·Sewon LeeCuihua Zhang
May 24, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Sewon LeeCuihua Zhang

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Citations

Jan 8, 2013·Reviews in Endocrine & Metabolic Disorders·J David Symons, E Dale Abel
Oct 12, 2012·Current Hypertension Reports·Adam R WendeE Dale Abel
Aug 26, 2014·Pharmacological Reports : PR·Grzegorz SłomianPrzemysław Nowak
May 31, 2014·Journal of Exercise Rehabilitation·Sewon Lee, Hyo-Bum Kwak
Sep 16, 2014·Trends in Cardiovascular Medicine·Lina ZhaoZhenqi Liu
Oct 15, 2013·Canadian Journal of Physiology and Pharmacology·Romana R GernerHerbert Tilg
Oct 13, 2012·Clinical and Experimental Hypertension : CHE·Omar F KhabourZeyad J El-Akawi
Sep 9, 2015·International Heart Journal·Shintaro KinugawaHiroyuki Tsutsui
Jul 5, 2015·International Journal of Cardiology·Si-Yu LiuYuan-Jian Li
Feb 20, 2015·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Amy L SindlerChristopher L Gentile
Jun 4, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Jian CaoNader G Abraham
May 3, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Meredith Kohr OwenJohnathan D Tune
May 23, 2014·Journal of Korean Medical Science·Yu Jin OhNack In Kim
Jun 28, 2019·Childhood Obesity·Hafize Emine SönmezSalim Çalışkan
Oct 3, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xuemei WangYining Yang
Mar 31, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Allison G HaysRobert G Weiss
Jul 4, 2018·Oxidative Medicine and Cellular Longevity·Andrzej FedorowiczStefan Chlopicki
Oct 23, 2018·Journal of Exercise Nutrition & Biochemistry·Hyun NamgoongSewon Lee
Apr 20, 2021·European Journal of Internal Medicine·Agostino Di CiaulaPiero Portincasa
May 15, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Jacob T CaldwellJudy M Muller-Delp

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