Adiponectin, adiposity, and insulin resistance in children and adolescents

The Journal of Clinical Endocrinology and Metabolism
Zubin PunthakeeMarie Lambert

Abstract

Determinants of adiponectin and its association with insulin resistance (IR) are less well studied in youth than in adults. The objective of the study was to describe, in youth, the age- and sex-specific distribution of adiponectin concentrations and the association with demographic, anthropometric, and lifestyle factors, parental diabetes, and markers of IR. We studied 1632 French Canadian youth aged 9, 13, and 16 yr who participated in the Québec Child and Adolescent Health and Social Survey, a province-wide, school-based survey conducted in 1999. Boys had lower adiponectin concentrations than girls by 17% (P < 0.0001). At age 16 yr, mean adiponectin concentrations were 27.7% (boys, P < 0.0001) and 13.3% (girls, P < 0.0001) lower than at age 9 yr (p(interaction) = 0.009). Mean adiponectin decreased for every unit increase in body mass index (BMI) Z-score by 8.1% in boys and 11.2% in girls (P < 0.0001). Growth-related change in BMI explained half the age effect in boys and all the age effect in girls. Self-reported pubertal status, physical activity, smoking, and parental diabetes were not independently associated with adiponectin. Fasting insulin and homeostasis model assessment-IR were not associated with adiponectin concent...Continue Reading

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