Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1

Free Radical Biology & Medicine
Haobo LiZhengyuan Xia

Abstract

Hyperglycemia-induced oxidative stress is implicated in the development of cardiomyopathy in diabetes that is associated with reduced adiponectin (APN) and heme oxygenase-1 (HO-1). Brahma-related gene 1 (Brg1) assists nuclear factor-erythroid-2-related factor-2 (Nrf2) to activate HO-1 to increase myocardial antioxidant capacity in response to oxidative stress. We hypothesized that reduced adiponectin (APN) impairs HO-1 induction which contributes to the development of diabetic cardiomyopathy, and that supplementation of APN may ameliorate diabetic cardiomyopathy by activating HO-1 through Nrf2 and Brg1 in diabetes. Control (C) and streptozotocin-induced diabetic (D) rats were untreated or treated with APN adenovirus (1×10(9) pfu) 3 weeks after diabetes induction and examined and terminated 1 week afterward. Rat left ventricular functions were assessed by a pressure-volume conductance system, before the rat hearts were removed to perform histological and biochemical assays. Four weeks after diabetes induction, D rats developed cardiac hypertrophy evidenced as increased ratio of heart weight to body weight, elevated myocardial collagen I content, and larger cardiomyocyte cross-sectional area (all P<0.05 vs C). Diabetes elevated c...Continue Reading

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Citations

Jul 3, 2015·Oxidative Medicine and Cellular Longevity·Md Abu Taher SagorMd Ashraful Alam
Mar 24, 2017·British Journal of Pharmacology·Thomas KietzmannAgnes Görlach
Dec 15, 2015·Circulation Research·Hui ZhangBin Zhou
Nov 5, 2017·The Journal of Pharmacology and Experimental Therapeutics·R Jason KirbySiobhan Malany
Dec 1, 2017·Physiological Genomics·Qin M Chen, Anthony J Maltagliati
Apr 30, 2020·American Journal of Physiology. Cell Physiology·Jake S RussellJohn P Headrick
May 26, 2020·Journal of Cellular and Molecular Medicine·Dan YanZhengyuan Xia
Aug 10, 2020·Cell Biology International·Jingyu DengWei Jiang
Jul 24, 2018·Oxidative Medicine and Cellular Longevity·Haobo LiHong Zheng
Aug 5, 2017·Oxidative Medicine and Cellular Longevity·Ni ZengFeng Xiao
May 3, 2019·The Korean Journal of Internal Medicine·Jun Young LeeJae Seok Kim
Apr 11, 2020·Cell Communication and Signaling : CCS·Deling ZhangChanghua Wang
Oct 6, 2020·Oxidative Medicine and Cellular Longevity·Shilong YouNaijin Zhang
Dec 20, 2019·Journal of Cellular and Molecular Medicine·Jierong LuoZhengyuan Xia
Aug 29, 2017·Oxidative Medicine and Cellular Longevity·Shiyan PengFeng Xiao
Nov 1, 2016·Expert Opinion on Therapeutic Targets·Shuai JiangWei Yi
May 16, 2019·Oxidative Medicine and Cellular Longevity·Chi XiaoLing-Bo Qian
Aug 29, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Takatoshi UchidaMakoto Aihara
Apr 23, 2021·Chinese Medical Journal·Wen-Bo HuangGui-Ling Xie
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Jia-Yue DuanLing-Qing Yuan

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