Adiponectin and cardiometabolic trait and mortality: where do we go?

Cardiovascular Research
Albert Youngwoo JangKwang Kon Koh

Abstract

Adiponectin is an adipocyte-derived cytokine known for its cardioprotective effects in preclinical studies. Early epidemiologic studies replicated these findings and drew great interest. Subsequent large-scale prospective cohorts, however, showed that adiponectin levels seemed not to relate to incident coronary artery disease (CAD). Even more surprisingly, a paradoxical increase of all-cause and cardiovascular (CV) mortality with increased adiponectin levels was reported. The adiponectin-mortality paradox has been explained by some groups asserting that adiponectin secretion is promoted by elevated natriuretic peptides (NP). Other groups have proposed that adiponectin is elevated due to adiponectin resistance in subjects with metabolic syndrome or heart failure (HF). However, there is no unifying theory that can clearly explain this paradox. In patients with HF with reduced ejection fraction (HFrEF), stretched cardiomyocytes secrete NPs, which further promote release of adiponectin from adipose tissue, leading to adiponectin resistance. On the other hand, adiponectin biology may differ in patients with heart failure with preserved ejection fraction (HFpEF), which constitutes 50% of all of HF. Most HFpEF patients are obese, whic...Continue Reading

References

Nov 10, 1995·The Journal of Biological Chemistry·P E SchererH F Lodish
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·A H KissebahA G Comuzzie
Aug 2, 2001·Nature Medicine·A H BergP E Scherer
Jul 13, 2002·Lancet·Robert S LindsayJonathan Krakoff
Nov 27, 2002·Circulation·Yoshihisa OkamotoYuji Matsuzawa
Apr 10, 2003·JAMA : the Journal of the American Medical Association·Katherine EspositoDario Giugliano
May 27, 2003·Diabetes Care·Jonathan KrakoffRobert S Lindsay
Jun 13, 2003·Nature·Toshimasa YamauchiTakashi Kadowaki
Aug 29, 2003·The Journal of Biological Chemistry·Hui ChenMichael J Quon
Nov 25, 2003·Diabetes Care·Norbert StefanP Antonio Tataranni
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Tobias PischonEric B Rimm
Nov 13, 2004·The Journal of Biological Chemistry·Ying LinPhilipp E Scherer
Nov 24, 2004·Nature Medicine·Rei ShibataKenneth Walsh
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert S LindsayLyle G Best
Dec 6, 2005·Journal of the American College of Cardiology·Kwang Kon KohMichael J Quon
Jan 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Daisuke FujiokaKiyotaka Kugiyama
Jan 25, 2006·The Journal of Biological Chemistry·Naoto KubotaTakashi Kadowaki
Aug 9, 2006·Circulation·Naveed SattarPeter H Whincup
Dec 1, 2006·The European Respiratory Journal·K G BlythA J Peacock
Feb 6, 2007·Journal of the American College of Cardiology·Seung Hwan HanKwang Kon Koh
Mar 14, 2007·Journal of the American College of Cardiology·Faquan LiangAndrew A Protter
Mar 14, 2007·Journal of the American College of Cardiology·Horng H Chen
Jan 15, 2008·International Journal of Cardiology·Hajime TakanoKiyotaka Kugiyama
May 31, 2008·Atherosclerosis·Ling TianYuchang Fu
Aug 21, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takahiro OharaMasafumi Kitakaze
Dec 9, 2008·International Journal of Cardiology·Kwang Kon KohEak Kyun Shin
May 30, 2009·Journal of the American College of Cardiology·Osamu TsukamotoMasafumi Kitakaze
Sep 8, 2009·Progress in Cardiovascular Diseases·Seung Hwan HanKwang Kon Koh
Oct 24, 2009·Endocrinology·Flora SamNoriyuki Ouchi
Jan 28, 2010·Circulation. Heart Failure·An M Van BerendoncksViviane M Conraads
Mar 20, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrea R NawrockiPhilipp E Scherer
Apr 13, 2010·The American Journal of Cardiology·Andreia BioloFlora Sam
May 28, 2010·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Sasiwarang Goya WannametheeNaveed Sattar
Nov 3, 2010·The Journal of Clinical Investigation·Martin S DenzelBarbara Ranscht

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