Adiponectin and leptin in human severe insulin resistance - diagnostic utility and biological insights

Biochimie
M P GroeneveldR K Semple

Abstract

There is an intimate interplay between systemic insulin action and the actions of the adipocyte-derived proteins leptin and adiponectin. Concordant findings in humans and rodents demonstrate that leptin gates critical physiological functions to the prevailing nutritional state, however the physiological functions of adiponectin are less convincingly established. Murine evidence suggests that adiponectin can exert insulin-sensitising effects, plasma concentrations of adiponectin in humans correlate in most populations with insulin sensitivity, and increasingly strong evidence suggests an association between common genetic variation around the adiponectin gene and diabetes. However rare and severe genetic variants lowering adiponectin levels have not been convincingly associated with insulin resistance, and the discordant and sometimes extreme hyperadiponectinaemia seen in patients with severe insulin resistance due to loss of insulin receptor function poses a challenge to the widely held view that low adiponectin in humans plays a role in causing prevalent insulin resistance. The mechanism underlying this phenomenon remains to be elucidated, but the best available evidence implicates increased production of adiponectin in states...Continue Reading

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Jul 14, 2012·Biochimie·Jean-Philippe Bastard, Bruno Fève
Jul 21, 2015·Journal of Pediatric Gastroenterology and Nutrition·Joanna GajewskaMonika Puzianowska-Kuźnicka
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