Adiponectin as a sepsis biomarker in dogs: Diagnostic and prognostic value.

Veterinary Clinical Pathology
Carlos TorrenteAsta Tvarijonaviciute

Abstract

Adiponectin (ADPN) is an adipocytokine with insulin-sensitizing, vascular-protective, and anti-inflammatory properties for which concentration changes occur in response to inflammation. Little is known about the regulation of ADPN and the impact of this adipocytokine in septic dogs. We aimed to assess the diagnostic and prognostic value of ADPN vs other traditional acute-phase proteins (APPs), such as albumin (ALB), haptoglobin (HPT), fibrinogen (FBG), ferritin (FRT), and C-reactive protein (CRP) in dogs with naturally acquired sepsis. This prospective observational study included 20 dogs with sepsis, 27 with low-grade systemic inflammation (LGSI), and 18 clinically healthy dogs as controls. For method analyses, plasma samples were obtained from all dogs on admission and then every 24-48 hours until discharge or death in the septic group. Septic dogs had lower ADPN (2.4 ± 0.46 vs 4.5 ± 0.41mg/L, P < .001) dand ALB (17 ± 1 vs 22 ± 0.8g/L, P = .002), and tended to have higher CRP (87 ± 4.8 vs 73 ± 4.1mg/L, P < .079) concentrations than dogs with LGSI on admission. Only ADPN and ALB were able to successfully discriminate animals with LGSI from those presenting with sepsis with areas under the curve (AUCs) for the receiver operatin...Continue Reading

References

Oct 8, 2003·Journal of Veterinary Internal Medicine·Armelle M de LaforcadeJohn E Rush
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Antonios M XydakisChristie M Ballantyne
Dec 5, 2006·Cardiovascular Research·Teresa A HopkinsKenneth Walsh
May 15, 2007·Gastroenterology·Michael K Badman, Jeffrey S Flier
Feb 7, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J HungJ P Beilby
Feb 26, 2008·The Veterinary Journal·J J CerónM Caldin
Jul 17, 2008·American Journal of Physiology. Endocrinology and Metabolism·Hwee TeohSubodh Verma
Nov 22, 2008·European Journal of Clinical Investigation·S KaserJ R Patsch
Apr 28, 2009·Veterinary Clinical Pathology·M Judith RadinBethany J Holycross
Jun 24, 2009·Critical Care : the Official Journal of the Critical Care Forum·Alexander KochChristian Trautwein
Jul 3, 2009·Critical Care : the Official Journal of the Critical Care Forum·Bala VenkateshJohn Prins
Sep 8, 2009·Progress in Cardiovascular Diseases·Seung Hwan HanKwang Kon Koh
Sep 18, 2009·Intensive Care Medicine·Jennifer M KaplanBasilia Zingarelli
Oct 14, 2009·Journal of Veterinary Emergency and Critical Care·Constance GebhardtBarbara Kohn
Aug 25, 2010·Journal of Veterinary Emergency and Critical Care·Maureen A LuschiniGretchen L Schoeffler
Oct 5, 2010·Critical Care Medicine·Allan J WalkeyRoss Summer
Dec 15, 2010·Veterinary Immunology and Immunopathology·Asta TvarijonaviciuteJose J Ceron
Feb 16, 2011·Journal of the American Veterinary Medical Association·Janet A GrimesMary Ann G Radlinksy
May 19, 2011·Critical Care : the Official Journal of the Critical Care Forum·Katherine RobinsonBala Venkatesh
Mar 13, 2012·Journal of Veterinary Internal Medicine·A E DeClueM Harmon
Jan 4, 2013·Reproduction in Domestic Animals = Zuchthygiene·I KarlssonS Wernersson
Nov 26, 2013·Comparative Immunology, Microbiology and Infectious Diseases·S Martinez-SubielaG Baneth
Oct 15, 2014·Journal of Veterinary Internal Medicine·J PaekM-P Yang
Dec 30, 2014·Journal of Veterinary Emergency and Critical Care·Amy E DickinsonIain Keir
Apr 14, 2015·Veterinary Clinical Pathology·Julia Schüttler, Stephan Neumann
Jul 15, 2015·Journal of Veterinary Emergency and Critical Care·Carlos TorrenteRafael Ruiz de Gopegui
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Mar 18, 2016·Critical Care : the Official Journal of the Critical Care Forum·Jessica A PalakshappaNuala J Meyer
Aug 31, 2016·Journal of Veterinary Internal Medicine·H-S KimM-P Yang
Sep 8, 2016·Journal of Inflammation·Andreas HillenbrandUwe Knippschild
Oct 28, 2016·Journal of Inflammation Research·XianFeng WangVidula Vachharajani
Nov 22, 2016·Disease Markers·Mark LueddeChristoph Roderburg
Jun 14, 2017·Journal of Veterinary Internal Medicine·M TropfH Y Weng

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