Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury

Scientific Reports
Huafeng WangRongxin Zhang

Abstract

Adiponectin is an adipocyte-derived circulating protein with beneficial effects on injured livers. Adiponectin-deficient (adipo(-/-)) mice develop enhanced liver fibrosis, suggesting that adiponectin could be a therapeutic target for liver injury. In the present study, we investigated the protective role of ADP355, an adiponectin-based active short peptide, in thioacetamide (TAA)-induced acute injury and chronic liver fibrosis in mice. ADP355 remarkably reduced TAA-induced necroinflammation and liver fibrosis. ADP355 treatment increased liver glycogen, decreased serum alanine transaminase and alkaline phosphatase activity, and promoted body weight gain, hyper-proliferation and hypo-apoptosis. In addition, ADP355 administration suppressed the TAA-induced activation of hepatic stellate cells and macrophages in the liver. These were associated with the inactivation of TGF-β1/SMAD2 signaling and the promotion of AMPK and STAT3 signaling. Sensitivity of adipo(-/-) mice to chronic liver injury was decreased with ADP355. In conclusion, ADP355 could mimic adiponectin's action and may be suitable for the preclinical or clinical therapy of chronic liver injury.

References

Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·N SandersonS S Thorgeirsson
Jun 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·C A RiveraR G Thurman
Mar 19, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Axel M GressnerSteven Dooley
May 29, 2002·The Journal of Biological Chemistry·Wei LiRebecca Taub
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hajime HondaNobuhiro Sato
Feb 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Thomas WelteXin-Yuan Fu
Jun 13, 2003·Nature·Toshimasa YamauchiTakashi Kadowaki
Jul 8, 2003·The Journal of Pathology·Pierre Bedossa, Valérie Paradis
Jan 16, 2004·Gastroenterology·Yoshihiro KamadaYuji Matsuzawa
Mar 23, 2004·Biochemical and Biophysical Research Communications·Meghan C Wulster-RadcliffeMichael E Spurlock
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Neeraj K SaxenaFrank A Anania
Oct 2, 2004·Nature Reviews. Molecular Cell Biology·Rebecca Taub
Feb 4, 2005·The Journal of Clinical Investigation·Ramón Bataller, David A Brenner
May 18, 2005·Endocrine Reviews·Takashi Kadowaki, Toshimasa Yamauchi
Sep 10, 2005·Apoptosis : an International Journal on Programmed Cell Death·A M ElsharkawyD A Mann
Jan 18, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Varsha ThakurLaura E Nagy
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nelson FaustoKimberly J Riehle
May 9, 2007·Gastroenterology·Samuele De MinicisRobert F Schwabe
Jan 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Masayuki Adachi, David A Brenner
Mar 13, 2008·The Biochemical Journal·Karen WallaceMatthew C Wright
Apr 11, 2008·Journal of Gastroenterology and Hepatology·Honglian HuangLaura E Nagy
Jul 8, 2008·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Cristiana Bertolani, Fabio Marra
Jun 19, 2009·Inflammation & Allergy Drug Targets·Felix HeymannFrank Tacke
Jul 1, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Run-Zhe ShuZhu-Gang Wang
Jul 29, 2010·Seminars in Liver Disease·Thomas A Wynn, Luke Barron
Feb 25, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jennifer K PeppingAnnadora J Bruce-Keller

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Citations

Mar 7, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Lingman MaKejiang Lin
Jul 1, 2017·International Journal of Molecular Sciences·Christa BuechlerCharalampos Aslanidis
Jul 4, 2018·The Journal of Endocrinology·Sujith RajanAnil Nilkanth Gaikwad
Apr 17, 2019·Expert Opinion on Therapeutic Targets·Keisaku SatoGianfranco Alpini
Oct 12, 2018·The Journal of Endocrinology·Sujith RajanAnil Gaikwad
Apr 25, 2020·International Journal of Molecular Sciences·Claudia C DarmawanJe-Ho Mun
Aug 29, 2019·Frontiers in Endocrinology·Laszlo Otvos
Jul 30, 2020·Scientific Reports·Elizabeth A Kosmacek, Rebecca E Oberley-Deegan
Oct 20, 2020·Nephrology·Dan ZhaoXiaoxia Zhao
May 17, 2017·Advanced Drug Delivery Reviews·Takaaki HigashiYujin Hoshida
Mar 7, 2021·International Journal of Molecular Sciences·Yetirajam Rajesh, Devanand Sarkar
Aug 18, 2021·Biochemical and Biophysical Research Communications·Yusi ZhangBoquan Jin
Mar 27, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xixi ChengYurong Da

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Methods Mentioned

BETA
xenografts
nuclear translocation
flow cytometry
transgenic
Assay

Software Mentioned

Image
GraphPad
Quantity One 1 - D
Flow Jo
Pro Plus
GraphPad Prism

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