Adiponectin Gene Polymorphisms are Associated with Increased Risk of Colorectal Cancer

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Xiaoyu YangYinghua Ji

Abstract

This meta-analysis investigates the associations of adiponectin (ADIPOQ) genetic polymorphisms with the susceptibility to colorectal cancer (CRC). 2 reviewers independently searched 6 databases - PubMed, Cochrane Library, Ovid, Embase, China National Knowledge Infrastructure (CNKI) and Wanfang databases - to identify published studies relevant to adiponectin gene polymorphisms and CRC. Studies retrieved from database searches were screened using our stringent inclusion and exclusion criteria. Full texts of the selected studies were accessed and related data was extracted using a standardized data extraction form. Comprehensive Meta-analysis 2.0 software was used for statistical analyses. A total of 188 studies were initially retrieved from database search, and 6 studies were eventually selected, through a rigorous screening process, for inclusion in this meta-analysis. The 6 studies contained a total of 1897 patients (Asians: 1190; white: 707) with CRC in case group and 2475 healthy controls (Asians: 1325; white: 1150) in the control group. Results of the current meta-analysis revealed that the rs2241766 T>G single-nucleotide polymorphisms (SNP) increase the risk of CRC; rs1501299 G>T under dominant model was associated with in...Continue Reading

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Citations

Mar 8, 2016·Leukemia & Lymphoma·Andrea NicolatoMarcio Nucci
Sep 21, 2019·Molecular Biology Reports·Sarvari GerikiAruna P Kumari
Oct 25, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiaoli ZhaoYulan Jin
Sep 27, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jian-Xin WangYan-Feng Lv
Dec 8, 2020·Expert Opinion on Drug Metabolism & Toxicology·Eleonora PozziGuido Cavaletti

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Methods Mentioned

BETA
genotyping

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