Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men.

The Journal of Nutrition
Pablo Perez-MartinezJose M Ordovas

Abstract

Adiponectin (adipoQ) gene variants have been associated with type 2 diabetes mellitus and insulin resistance. Our aim was to examine whether the presence of several polymorphisms at the adipoQ gene locus (-11391 G > A, -11377 C > G, 45 T > G, and 276 G > T) influences the insulin sensitivity to dietary fat. Healthy volunteers (30 men and 29 women) consumed 3 diets for 4 wk each: an initial period during which all subjects consumed a SFA-rich diet (38% total fat, 20% SFA), followed by a carbohydrate-rich diet (CHO) (30% total fat, 55% carbohydrate) or a monounsaturated fatty acid (MUFA)-rich diet (38% total fat, 22% MUFA) following a randomized, crossover design. After participants consumed each diet, we tested peripheral insulin sensitivity with the insulin suppression test and measured plasma adiponectin concentrations. C/C homozygous men for the -11377 C > G single nucleotide polymorphism (SNP) had a significantly greater decrease in the steady-state plasma glucose concentrations when changing from the SFA-rich (8.95 +/- 0.6 mmol/L) to the MUFA-rich (6.04 +/- 0.31 mmol/L) and CHO-rich (6.35 +/- 0.38 mmol/L) diets than did those carrying the minor G allele (SFA, 6.65 +/- 0.4 mmol/L; MUFA, 6.45 +/- 0.4 mmol/L; CHO, 5.83 +/- 0.3...Continue Reading

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Citations

Jan 1, 2010·Journal of Nutrigenetics and Nutrigenomics·Amelia MartiJ Alfredo Martínez
Nov 19, 2011·Molecular Nutrition & Food Research·Pablo Perez-MartinezJose Lopez-Miranda
Apr 4, 2013·Current Opinion in Cardiology·Antonio Garcia-RiosPablo Perez-Martinez
Dec 10, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Caren E Smith, José M Ordovás
Sep 22, 2009·Arquivos brasileiros de endocrinologia e metabologia·Thais SteemburgoJosé Alfredo Martínez
Mar 11, 2011·The American Journal of Clinical Nutrition·Pablo Perez-MartinezJose Lopez-Miranda
May 10, 2013·The Journal of Nutrition·Aseel AlsalehUNKNOWN MARINA study team
Dec 10, 2016·International Journal of Food Sciences and Nutrition·Akram KabiriAhmad Esmaillzadeh
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