Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes.

Diabetes
Lu QiFrank B Hu

Abstract

Adiponectin is an adipocyte-derived hormone that has shown anti-inflammatory and antiatherogenic effects. We assessed the associations of variants in the adiponectin gene (ADIPOQ) with circulating adiponectin levels and cardiovascular risk among women with type 2 diabetes. Of 989 diabetic women from the Nurses' Health Study, 285 developed cardiovascular disease (CVD) during follow-up through 2000. We genotyped five ADIPOQ polymorphisms in the CVD case and control subjects. A promoter polymorphism -11365C-->G was significantly associated with lower plasma adiponectin levels (P = 0.004). The homozygotes of allele -4034C were significantly associated with approximately 60% increased cardiovascular risk (odds ratio 1.62 [95% CI 1.07-2.45]). Adjustment for age, BMI, and other covariates did not appreciably change the associations. In addition, a common haplotype possessing allele +276T (CAATT) was associated with a significantly lower CVD risk than the most common haplotype (CAATG) (0.70 [0.50-0.98]). In our meta-analysis of 827 CVD case and 1,887 CVD-free control subjects, polymorphism +276G-->T was significantly associated with approximately 45% (20-62%) decreased CVD risk under a recessive inheritance mode in diabetic patients. I...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 1, 1993·Medicine and Science in Sports and Exercise·B E AinsworthR S Paffenbarger
Apr 16, 1996·Biochemical and Biophysical Research Communications·K MaedaK Matsubara
May 3, 1996·The Journal of Biological Chemistry·E HuB M Spiegelman
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·K HottaY Matsuzawa
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·A H KissebahA G Comuzzie
Aug 2, 2001·Nature Medicine·A H BergP E Scherer
Mar 26, 2003·Clinical Chemistry·Tobias PischonEric B Rimm
Jul 16, 2003·Hypertension·Noriyuki OuchiYuji Matsuzawa
Mar 11, 2004·Annals of Human Genetics·D A TregouetJ L Golmard
Jun 24, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·C LacquemantJ Ruiz

❮ Previous
Next ❯

Citations

Oct 2, 2008·JAMA : the Journal of the American Medical Association·Virginia G KaklamaniBoris Pasche
Mar 15, 2011·Molecular Biology Reports·Nasser M Al-DaghriTajamul Hussain
Sep 14, 2010·Current Diabetes Reports·Alessandro Doria
Nov 16, 2012·World Journal of Pediatrics : WJP·Wanvisa UdomsinprasertYong Poovorawan
Dec 12, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hui-Jie FanYan-Ru Qin
Jan 13, 2011·European Journal of Clinical Nutrition·C Stryjecki, D M Mutch
Jul 18, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jonas Axelsson
Dec 20, 2007·Current Opinion in Nephrology and Hypertension·Jonas Axelsson, Peter Stenvinkel
May 3, 2008·Cancer Research·Virginia G KaklamaniChristos Mantzoros
Oct 1, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Preet K DhillonJing Ma
Apr 23, 2008·Journal of Lipid Research·Stephen J PetersonNader G Abraham
Aug 8, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Yi-Cheng ChangLee-Ming Chuang
Oct 3, 2008·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Nicole Y SourenAimee D C Paulussen
Sep 6, 2007·The Tohoku Journal of Experimental Medicine·Zeynep EyiletenUmit Ozyurda
Sep 14, 2012·The Review of Diabetic Studies : RDS·Mariana MureaBarry I Freedman
Jan 15, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Ken KishidaIichiro Shimomura
Aug 30, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Sami Alkayyali, Valeriya Lyssenko
Mar 20, 2010·Mediators of Inflammation·Elizabeth HijonaLuis Bujanda
Aug 14, 2009·Nutrition Reviews·Lu Qi
Jul 25, 2006·Expert Opinion on Investigational Drugs·Diana BarbChristos S Mantzoros
Oct 22, 2013·Metabolism: Clinical and Experimental·Stergios A PolyzosChristos S Mantzoros
Dec 25, 2012·Metabolism: Clinical and Experimental·Eun Yeong ChoeChristos S Mantzoros
Mar 28, 2012·Biochimie·Jana BreitfeldPeter Kovacs
Jul 14, 2010·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Yanrui WuChunjie Xiao
Jul 14, 2010·Cardiology Clinics·Dan Farbstein, Andrew P Levy
Feb 3, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Martin LaclaustraJosé M Ordovas
Jul 9, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fabio Marra, Cristiana Bertolani
Mar 4, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni MussoMaurizio Cassader
Sep 19, 2007·Journal of Internal Medicine·K Clement, D Langin

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.