Abstract
The relationship between asthma and obesity is well established, although the pathophysiological mechanisms linking both diseases remain unknown. Adiponectin is a hormone secreted by adipose cells, plays a role in the modulation of inflammation and may be the key linking these two types of inflammation. We conducted a cross-sectional study with asthma with different body mass indices (BMI); the patients were classified as eutrophic, overweight, or obese. We assessed disease control using the GINA consensus, and the levels of adiponectin, C-reactive protein (CRP) and interleukin 33 (IL-33) in each of the patients. We evaluated 75 of the 96 patients eligible for the study, including 25 in each BMI group. The CRP levels were significantly higher in the obese patients compared with both the eutrophic (p = 0.01) and the overweight (p = 0.03) patients. The mean adiponectin level was 21.82 ± 9.93 mg/L for the eutrophic asthmatics, which is a level that was significantly higher than in the overweight (15.31 ± 6.27 mg/L, p = 0.0140) and the obese (16.69 ± 11.45 mg/L, p = 0.0287) patients. The patients with higher adiponectin levels exhibited smaller FEV1 (p = 0.02) and lower FVC (p = 0.003). The IL-33 levels were not different between t...Continue Reading
References
Jul 1, 1991·The American Review of Respiratory Disease·M C LiuL M Lichtenstein
Jan 1, 1993·Science·G S HotamisligilB M Spiegelman
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·A SpanevelloG Michetti
Oct 2, 2002·European Journal of Immunology·Sandrine LécartHans Yssel
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Jan 17, 2004·Endocrinology·John N FainSuleiman W Bahouth
Mar 23, 2004·Biochemical and Biophysical Research Communications·Meghan C Wulster-RadcliffeMichael E Spurlock
Apr 21, 2004·Circulation·Masahiro KumadaYuji Matsuzawa
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takayuki MasakiHironobu Yoshimatsu
Sep 17, 2004·Journal of Rehabilitation Medicine·Birgit WolffArmin Stucki
May 4, 2005·The Journal of Allergy and Clinical Immunology·Earl S Ford
Jul 9, 2005·Diabetes Research and Clinical Practice·Hermes FlorezRonald Goldberg
Oct 26, 2005·Biochemical Society Transactions·P Trayhurn, I S Wood
Nov 3, 2005·The European Respiratory Journal·R PellegrinoJ Wanger
Nov 16, 2005·Immunity·Jochen SchmitzRobert A Kastelein
Nov 22, 2005·Pharmacology & Therapeutics·Stephanie A Shore, Richard A Johnston
Aug 8, 2006·The Journal of Allergy and Clinical Immunology·Stephanie A ShoreChristopher Hug
Apr 9, 2008·Thorax·A SoodD R Jacobs
Oct 7, 2008·PloS One·Christine MoussionJean-Philippe Girard
Jan 27, 2009·American Journal of Respiratory Cell and Molecular Biology·Benjamin D MedoffAndrew D Luster
Oct 31, 2009·Journal of Applied Physiology·Cheryl M SalomeNorbert Berend
Jul 17, 2010·Circulation Research·Ashley M MillerFoo Y Liew
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Keisuke ObokiSusumu Nakae
Aug 30, 2011·Journal of Inflammation·Ashley M Miller
Sep 29, 2011·Biochimica Et Biophysica Acta·Njira L LugogoMonica Kraft
Oct 19, 2011·Frontiers in Pharmacology·Akshay SoodDavid R Jacobs
Apr 12, 2012·American Journal of Respiratory and Critical Care Medicine·Akshay SoodDavid R Jacobs
Citations
Jul 14, 2016·Multidisciplinary Respiratory Medicine·Thiago Thomaz MafortAgnaldo José Lopes
Jul 5, 2016·Pharmacology & Therapeutics·Linda SwedinMatthew C Catley
Jul 13, 2016·Immunology and Allergy Clinics of North America·Xiao Chloe Wan, Prescott G Woodruff
Jul 12, 2017·International Journal of Molecular Sciences·Mª Amelia Gomez-LlorenteCarolina Gomez-Llorente
Oct 12, 2018·Scandinavian Journal of Immunology·Edita GasiunieneBrigita Sitkauskiene
Aug 9, 2018·Scientific Reports·Takashi YamashitaJohn Varga
May 17, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Qin ZhaoXiuli Zuo
Dec 28, 2019·International Journal of Environmental Research and Public Health·Aleksandra RyłIwona Rotter
Mar 7, 2017·Allergologia et immunopathologia·J B ChenY J Jin
Sep 19, 2020·The European Respiratory Journal·Cherry A ThompsonLisa G Wood
Feb 26, 2021·Gene·Raísa Santos CoelhoRyan do Santos Costa
Apr 1, 2019·Annals of Dermatology·Hee-Seok SeoSeung-Phil Hong
May 20, 2021·Digestive Diseases and Sciences·Minghao XieLei Lian
Aug 28, 2021·International Journal of Molecular Sciences·Marina Ruxandra OteleaAgripina Rascu
Dec 23, 2019·Revue des maladies respiratoires·C GuguenJ-M Perotin