PMID: 25760347Mar 12, 2015Paper

Adiponectin in asthma: implications for phenotyping

Current Protein & Peptide Science
Ersilia NigroAndrea Bianco

Abstract

Asthma is a heterogeneous inflammatory airway disease, which exhibits multiple phenotypes, mainly defined by a combination of different clinical features. Asthma phenotypes include age at onset, smoking status, exacerbations frequency, and co-existence of obesity. Links between specific biological pathways and phenotypes are emerging. The genetic background together with detectable biomarkers could more accurately identify asthma phenotypes consistent with clinical-physiological characteristics and response to therapies. Several cross-sectional studies indicate a strict correlation between adipose tissue, obesity, and asthma suggesting that obesity is not only a risk factor for asthma but also a predictor of poor prognosis. Despite the strong clinical correlation between obesity and asthma, the underlying biological pathways have not been extensively investigated. Recently, a pivotal role for adiponectin has been recognized in physio-pathological conditions of lung. Adiponectin is expressed as a 247 residues long protein and secreted as oligomers of low, medium and high molecular weight. The larger oligomers seem to have a more pronounced insulinsensitizing, anti-atherogenic, and anti-inflammatory effects. Interestingly, the th...Continue Reading

Citations

Jun 4, 2016·International Journal of Surgery·Alessandro IzzoGennaro Mazzarella
Jun 4, 2016·International Journal of Surgery·Carmine GuarinoAndrea Bianco
Jul 5, 2016·Pharmacology & Therapeutics·Linda SwedinMatthew C Catley
Jul 30, 2016·Pulmonary Pharmacology & Therapeutics·Donato LacedoniaAurora Daniele
Jan 25, 2017·Pulmonary Pharmacology & Therapeutics·Andrea BiancoAurora Daniele
May 17, 2017·Pulmonary Pharmacology & Therapeutics·Michela IllianoSilvio Naviglio
Feb 23, 2019·International Journal of Molecular Sciences·Fabio PerrottaGermano Guerra
Oct 2, 2017·Journal of Medical Case Reports·Carlo IadevaiaAndrea Bianco
Jul 8, 2020·Journal of Clinical Medicine·Carmen Frontela-SasetaLuis García-Marcos
Mar 29, 2020·Biochemical Pharmacology·Naina MongaAmarjit S Naura

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