Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes

Biochemical and Biophysical Research Communications
Anna M WolfHerbert Tilg

Abstract

There is increasing evidence that the adipose tissue and immunologic processes are closely linked. The most abundant protein within the adipocyte is adiponectin. Our current work reports that adiponectin has potent immuno-suppressive properties, as it induces the production of the anti-inflammatory mediators IL-10 and IL-1RA in primary human monocytes, monocyte-derived macrophages, and dendritic cells. In addition, adiponectin significantly impaired the production of the pro-inflammatory cytokine IFN-gamma in human macrophages. Moreover, adiponectin-treated macrophages exhibit a reduced phagocytotic and allo-stimulatory capacity. However, we could not detect any functional deficits or phenotypic changes in adiponectin-treated monocytes and monocyte-derived DC. In summary, the presented data support the idea that adiponectin might be of critical relevance for cytokine regulation in obesity and fatty liver diseases affecting primarily macrophage functions. This might represent a fundamental link between over-nutrition and an impaired inflammatory immune response.

References

Jun 1, 1992·Immunology Today·M Howard, A O'Garra
Jan 1, 1980·Acta paediatrica Scandinavica·R K Chandra, K M Kutty
Jan 1, 1980·British Journal of Haematology·J PalmbladL Engstedt
Jun 18, 2002·Nature Medicine·Norikazu MaedaYuji Matsuzawa
Jan 10, 2003·The Journal of Biological Chemistry·Guillaume CharrièreLouis Casteilla
Dec 20, 2003·Current Drug Targets. Immune, Endocrine and Metabolic Disorders·Toshimasa YamauchiTakashi Kadowaki
Mar 23, 2004·Biochemical and Biophysical Research Communications·Meghan C Wulster-RadcliffeMichael E Spurlock

❮ Previous
Next ❯

Citations

May 2, 2009·Inflammatory Bowel Diseases·A BatraB Siegmund
Sep 30, 2010·Inflammatory Bowel Diseases·Razvan ArsenescuWillem J de Villiers
Dec 15, 2005·Archives of Pharmacal Research·Jee Hyun KangYong Kyun Roh
Nov 17, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·In Seok LeeRyowon Choue
Jun 13, 2012·Diabetologia·A T Turer, P E Scherer
Jul 24, 2010·Molecules and Cells·Mi-Jin KimSeung-Yoon Park
Sep 3, 2010·Wiener medizinische Wochenschrift·Carmen GelsingerChristoph F Ebenbichler
Feb 20, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Nicholas J ZyromskiKeith D Lillemoe
Jun 11, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hayder H Al-AzzawiNicholas J Zyromski
Mar 28, 2008·Current Diabetes Reports·Tongjian You, Barbara J Nicklas
Mar 16, 2013·Current Diabetes Reports·Eric Lontchi-YimagouAndre Pascal Kengne
Oct 22, 2010·Endocrine·Karine Brochu-GaudreauMarie-France Palin
Feb 3, 2011·Hepatology International·Tary A SalmanOmkolsoum M El-Haddad
Mar 19, 2013·The International Journal of Biochemistry & Cell Biology·Ersilia NigroAurora Daniele
Jul 4, 2012·Pulmonary Pharmacology & Therapeutics·Benjamin D Medoff
Sep 11, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Tim J T SutherlandRobert J Hancox
Jul 6, 2010·The Proceedings of the Nutrition Society·Robert F Grimble
Jun 15, 2010·The Proceedings of the Nutrition Society·María J Moreno-AliagaJ Alfredo Martínez
Mar 15, 2012·The Proceedings of the Nutrition Society·J Justin Milner, Melinda A Beck
Jan 16, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshitaka MoriAi Fujimaki
Sep 26, 2006·Nature Reviews. Immunology·Herbert Tilg, Alexander R Moschen
Jul 21, 2009·The Journal of Biological Chemistry·Eduardo J FolcoPeter Libby
Nov 19, 2011·Human Molecular Genetics·Agatha SchlüterAurora Pujol
Mar 23, 2006·Pancreas·Eija TukiainenHeikki Repo
Nov 21, 2009·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Gertraud MaskarinecRobert V Cooney
Sep 18, 2007·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Tomoko KawaiKazuhito Rokutan
Feb 19, 2013·Transplantation·Timm HeinbokelStefan G Tullius
Apr 11, 2008·Journal of Gastroenterology and Hepatology·Honglian HuangLaura E Nagy
Jun 21, 2008·Journal of Gastroenterology and Hepatology·Vincent Wai-Sun WongHenry Lik-Yuen Chan
Oct 2, 2008·Nephrology·Bogdan ManolescuOlivera Lupescu
Oct 14, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jamie Chung Mei LamMary Sau Man Ip
Apr 24, 2007·Cephalalgia : an International Journal of Headache·B L PeterlinA M Rapoport
Jul 21, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yanjun ZhangJulia Wanjiru Kimondo
Nov 21, 2009·Journal of Applied Physiology·Akshay Sood
Oct 31, 2009·Journal of Applied Physiology·Njira L LugogoAnne E Dixon
Apr 24, 2012·Journal of Nutrition and Metabolism·Faloia EmanuelaBoscaro Marco
Aug 19, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Stephanie M GeorgeRachel Ballard-Barbash
Oct 1, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Preet K DhillonJing Ma

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.