Adiponectin inhibits allograft rejection in murine cardiac transplantation.

Transplantation
Yoshihisa OkamotoPeter Libby

Abstract

Low levels of plasma adiponectin, an adipocytokine that possesses anti-inflammatory and antiatherogenic properties, frequently observed among obese subjects correlate with higher prevalence of several cardiovascular diseases. This study investigated whether adiponectin modulates allograft rejection in major histocompatibility complex class II-mismatched cardiac transplants. We heterotopically transplanted Bm12 allografts into adiponectin-deficient (APN-/-, C57BL/6 background) or wild-type (APN+/+) mice. Some APN-/- mice received adiponectin reconstitution by adenovirus. Histologic analyses assessed allograft rejection, and real-time reverse-transcriptase polymerase chain reaction evaluated the genes for cytokines/chemokines associated with the immune and inflammatory responses. In addition, we tested the effect of adiponectin on proliferation and cytokine/chemokine production in mouse T lymphocytes stimulated in vitro with anti-CD3 antibodies. Allografts transplanted to APN-/- mice showed severe acute rejection relative to transplants in APN+/+ hosts accompanied by increased accumulation of CD4- and CD8-positive T lymphocytes and Mac3-positive macrophages. Adiponectin provision by adenovirus in APN-/- mice reversed these exacer...Continue Reading

References

Jun 18, 2002·Nature Medicine·Norikazu MaedaYuji Matsuzawa
Mar 18, 2003·The Journal of Clinical Investigation·Galina K SukhovaGuo-Ping Shi
Nov 24, 2004·Nature Medicine·Rei ShibataKenneth Walsh
Sep 7, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kathleen L GradyUNKNOWN Cardiac Transplant Research Database Group
Feb 9, 2006·Clinical Science·Yoshihisa OkamotoPeter Libby
Jun 1, 2006·Circulation·Hisanori KosugeMitsuaki Isobe
Dec 30, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Aki HiugeTohru Funahashi
Mar 30, 2007·Atherosclerosis·Toshiyuki TakagiIichiro Shimomura
Apr 25, 2007·Transplantation·Jun-ichi SuzukiMitsuaki Isobe

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Citations

Sep 6, 2012·The Journal of Biological Chemistry·Xiang ChengPeter Libby
Mar 1, 2012·Transplantation·Annemarie WeissenbacherRobert Öllinger
Feb 19, 2013·Transplantation·Timm HeinbokelStefan G Tullius
Jul 9, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Takashi IshiharaMitsuaki Isobe
Apr 18, 2013·PLoS Computational Biology·Gabriela V Cohen FreueUNKNOWN Biomarkers in Transplantation and the NCE CECR Prevention of Organ Failure Centre of Excellence Teams
Dec 19, 2013·Current Treatment Options in Cardiovascular Medicine·Rodolfo Denadai Benatti, David O Taylor
Aug 7, 2010·Current Opinion in Organ Transplantation·Jennifer R Wehner, William M Baldwin
Jan 13, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D WuM K Levings
Mar 26, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Yan ChenPaul Kwong Hang Tam
Nov 26, 2010·International Immunopharmacology·Julia Yuen Shan TsangPaul Kwong Hang Tam
Feb 13, 2013·European Journal of Immunology·Sabrina WilkCarmen Scheibenbogen
May 4, 2011·European Journal of Immunology·Sabrina WilkCarsten Skurk
Sep 25, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Catherine QuinlanKjell Tullus
Jul 16, 2013·Cytokine·Giamila Fantuzzi
Feb 24, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M QuanteS G Tullius
Mar 24, 2016·Transplantation·Luciana L MolineroMaria-Luisa Alegre
Dec 4, 2015·BioMed Research International·B E Martínez-CarrilloV Rivera-Aguilar
Oct 11, 2016·Seminars in Immunology·Fortunata CarboneGiuseppe Matarese
Nov 21, 2020·Transplantation·Naoaki SakataShohta Kodama

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