Adiponectin is independently associated with apolipoprotein B to A-1 ratio in Koreans

Metabolism: Clinical and Experimental
Jong Suk ParkHyun Chul Lee

Abstract

Apolipoprotein B to A-1 (apo B/A-1) ratio is reportedly a better predictor of atherosclerotic vascular disease than low-density lipoprotein cholesterol (LDL-C). The aim of this study was to assess the association of serum apo B/A-1 ratio with insulin resistance and adiponectin in patients with different grades of glucose intolerance. Patients were divided according to glucose tolerance into 3 groups: normal glucose tolerance without metabolic syndrome (n = 229), impaired fasting glucose (subjects with fasting plasma glucose level between 100 and 125 mg/dL, n = 658), and type 2 diabetes mellitus (n = 381). Serum concentrations of apo B, apo A-1, glucose, total cholesterol (TC), triglycerides, and high-density lipoprotein cholesterol (HDL-C) and adiponectin were measured. Insulin resistance was estimated by the homeostasis model assessment of insulin resistance index (HOMA-IR). There were significant differences in metabolic parameters among the groups, including waist circumference, insulin, HOMA-IR, and apo B/A-1 ratio, which increased sequentially with glucose intolerance, whereas adiponectin level decreased with increasing severity of glucose intolerance. The apo B/A-1 ratio was significantly correlated with TC, triglycerides...Continue Reading

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Citations

Feb 4, 2011·Scandinavian Cardiovascular Journal : SCJ·Kamran AhmedAnita Hurtig-Wennlof
Jan 9, 2018·Journal of the Endocrine Society·Vanessa DeClercqRoger S McLeod
Jan 11, 2018·BioMed Research International·Vaida BaltrūnienėVirginija Grabauskienė
Nov 11, 2020·Metabolic Syndrome and Related Disorders·Ewelina Pałkowska-GoździkGrzegorz Gielerak

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