Abstract
Apolipoprotein B to A-1 (apo B/A-1) ratio is reportedly a better predictor of atherosclerotic vascular disease than low-density lipoprotein cholesterol (LDL-C). The aim of this study was to assess the association of serum apo B/A-1 ratio with insulin resistance and adiponectin in patients with different grades of glucose intolerance. Patients were divided according to glucose tolerance into 3 groups: normal glucose tolerance without metabolic syndrome (n = 229), impaired fasting glucose (subjects with fasting plasma glucose level between 100 and 125 mg/dL, n = 658), and type 2 diabetes mellitus (n = 381). Serum concentrations of apo B, apo A-1, glucose, total cholesterol (TC), triglycerides, and high-density lipoprotein cholesterol (HDL-C) and adiponectin were measured. Insulin resistance was estimated by the homeostasis model assessment of insulin resistance index (HOMA-IR). There were significant differences in metabolic parameters among the groups, including waist circumference, insulin, HOMA-IR, and apo B/A-1 ratio, which increased sequentially with glucose intolerance, whereas adiponectin level decreased with increasing severity of glucose intolerance. The apo B/A-1 ratio was significantly correlated with TC, triglycerides...Continue Reading
References
Jun 1, 1991·Diabetologia·E FerranniniM P Stern
Apr 1, 1996·Circulation·J R PetrieJ M Connell
Jun 1, 1996·The Journal of Clinical Investigation·H O SteinbergA D Baron
Aug 26, 1998·Circulation·M PyöräläK Pyörälä
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jan 5, 2002·Lancet·G WalldiusE Steiner
May 9, 2002·Atherosclerosis·Maziar RahmaniFereidoun Azizi
Apr 30, 2003·Diabetes Care·Laurence DuvillardBruno Vergès
Oct 29, 2003·Circulation·Ken WilliamsSteven M Haffner
Nov 1, 2003·Thrombosis Research·Zofia DzielińskaWitold Ruzyłło
Dec 17, 2003·Annals of Human Biology·B FinkJ T Manning
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Tobias PischonEric B Rimm
May 8, 2004·Metabolism: Clinical and Experimental·Tsutomu KazumiGen Yoshino
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Barry J Goldstein, Rosario Scalia
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Roberto BarattaLucia Frittitta
Sep 4, 2004·Stroke; a Journal of Cerebral Circulation·Karin WallenfeldtBjörn Fagerberg
Nov 9, 2004·Atherosclerosis·James P CorsettiCharles E Sparks
Jan 29, 2005·Diabetes·Matthias B SchulzeFrank B Hu
Mar 1, 2005·Diabetes·Theodore W K NgP Hugh R Barrett
Mar 11, 2005·Endocrine·Katarzyna DunajskaPrzemysław Nowicki
Apr 13, 2005·Atherosclerosis·Ki Chul Sung, Sang Tai Hwang
Nov 8, 2005·Lancet·Salim YusufUNKNOWN INTERHEART Study Investigators
Apr 25, 2006·Journal of Internal Medicine·G Walldius, I Jungner
Nov 30, 2006·Biochemical and Biophysical Research Communications·Markus NeumeierChrista Buechler
Sep 4, 2007·European Heart Journal·Justo Sierra-JohnsonRachel M Fisher
May 27, 2008·Metabolism: Clinical and Experimental·Soo Jin YoonSun Ha Jee
Aug 8, 2008·Diabetes Research and Clinical Practice·Kazunari MatsumotoYukitaka Ueki
Citations
Feb 4, 2011·Scandinavian Cardiovascular Journal : SCJ·Kamran AhmedAnita Hurtig-Wennlof
Sep 24, 2011·Clinical Biochemistry·Zhu-zhi WenJing-feng Wang
Dec 22, 2011·Yonsei Medical Journal·Hoyoun WonNamsik Chung
Jan 9, 2018·Journal of the Endocrine Society·Vanessa DeClercqRoger S McLeod
Jan 11, 2018·BioMed Research International·Vaida BaltrūnienėVirginija Grabauskienė
Nov 11, 2020·Metabolic Syndrome and Related Disorders·Ewelina Pałkowska-GoździkGrzegorz Gielerak