Adiponectin is released from the heart in patients with heart failure

International Journal of Cardiology
Hajime TakanoKiyotaka Kugiyama

Abstract

Plasma levels of adiponectin are decreased in patients with ischemic heart disease, but increased in patients with heart failure (HF). The source of increased adiponectin levels in patients with HF remains unknown. This study examined whether adiponectin, an adipocyte-derived protein with cardioprotective actions, is released from the heart in patients with HF. Plasma adiponectin levels sampled from the aorta, coronary sinus (CS), and peripheral vein (PV) were measure by ELISA in 138 consecutive patients with left ventricular ejection fraction (LVEF) <40% and in 40 normal controls. PV adiponectin levels were significantly higher in patients with either non-ischemic HF (n=81) or ischemic HF (n=57) than controls; levels were similar between patients with non-ischemic HF and those with ischemic HF. There was a significant step-up in adiponectin levels from the aorta to the CS in patients with either non-ischemic HF or ischemic HF but not in controls. The CS-aorta difference in adiponectin levels, which reflect cardiac release of adiponectin, positively correlated with PV levels in patients with either non-ischemic HF or ischemic HF. The CS-aorta difference in adiponectin levels positively correlated with PV levels of brain natriur...Continue Reading

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Citations

Apr 24, 2013·Journal of Cardiovascular Translational Research·Deepa M Gopal, Flora Sam
Oct 15, 2013·Canadian Journal of Physiology and Pharmacology·Morris KarmazynVenkatesh Rajapurohitam
Mar 2, 2011·The American Journal of the Medical Sciences·Bingyan GuoMei Wang
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