Adiponectin may mediate the association between omentin, circulating lipids and insulin sensitivity: results from the KORA F4 study

European Journal of Endocrinology
Christian HerderB Thorand

Abstract

Reduced circulating omentin levels have been reported in obesity and type 2 diabetes, but data were mostly derived from univariate analyses in small study samples. This study aimed to investigate the relationship between omentin, abnormal glucose tolerance and related metabolic factors in a large population-based cross-sectional study. Serum omentin was measured by ELISA in 1092 participants of the German KORA F4 survey (2006-2008). Associations between omentin serum levels, glucose tolerance (assessed with an oral glucose tolerance test) and diabetes-related factors were estimated using logistic and linear regression models respectively. Serum levels of omentin were not related to categories of glucose tolerance. However, serum omentin was positively associated with whole-body insulin sensitivity index (ISI (composite)) and HDL cholesterol and showed inverse associations with 2-h post-load glucose, fasting insulin, homeostasis model assessment-estimated insulin resistance, BMI and triglycerides (all P≤0.03 after adjustment for age, sex and lifestyle factors). Further adjustment for BMI and/or serum lipids attenuated the associations with parameters of glucose metabolism, whereas adjustment for serum adiponectin virtually aboli...Continue Reading

References

Mar 15, 2006·American Journal of Physiology. Endocrinology and Metabolism·Rong-Ze YangDa-Wei Gong
Mar 3, 2007·Diabetes·Celia M de Souza BatistaJohn C McLenithan
Jul 7, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew S LeveyThomas Hostetter
Jul 9, 2009·The Journal of Clinical Endocrinology and Metabolism·J M Moreno-NavarreteJ M Fernández-Real
Jul 9, 2009·JAMA : the Journal of the American Medical Association·Shanshan LiRob M van Dam
Dec 17, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·W RathmannC Meisinger
Apr 13, 2010·Nutrition & Metabolism·José María Moreno-NavarreteJosé Manuel Fernández-Real
Apr 17, 2010·PloS One·Veikko SalomaaStefan Blankenberg
Jul 1, 2010·Diabetes Care·Ralph A DeFronzo, Masafumi Matsuda
Jan 6, 2011·Journal of Internal Medicine·K LuotolaUNKNOWN Health 2000 and FINRISK97 Studies
Mar 5, 2011·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·P YanR Li
Apr 26, 2011·Biochemical and Biophysical Research Communications·Hideyuki YamawakiYukio Hara
Jul 12, 2011·Trends in Cardiovascular Medicine·Bee K TanHarpal S Randeva
Jul 31, 2012·Biochemical and Biophysical Research Communications·Xia ZhongDeya Shang
Jan 11, 2013·The Journal of Clinical Endocrinology and Metabolism·Ishwarlal JialalAndrew A Bremer
Apr 23, 2013·Annals of Clinical Biochemistry·Qiuyan WangJian Kang
May 15, 2013·Cell Metabolism·William L HollandPhilipp E Scherer
Sep 18, 2013·Diabetes, Obesity & Metabolism·C HerderD M Ouwens
Oct 3, 2013·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·G CatliE Bober
Jan 15, 2014·Asian Pacific Journal of Tropical Medicine·Xiu-Hua WangXiao-Qing Wang

❮ Previous
Next ❯

Citations

Jun 23, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·C HerderUNKNOWN KORA Study Group
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marcelina SperlingKrystyna Czyzewska
Sep 2, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Noriyuki OuchiToyoaki Murohara
Jul 7, 2015·Cytokine·María F GarcésJorge E Caminos
Jan 24, 2017·The Journal of Clinical Investigation·Elisa Álvarez HernándezMichael Roden
Feb 2, 2017·Cardiovascular Diabetology·Christian HerderBarbara Thorand
May 12, 2017·Mediators of Inflammation·Daniel Azamar-LlamasJanette Furuzawa-Carballeda
Jan 15, 2018·Hormone Molecular Biology and Clinical Investigation·Antoaneta GatevaZdravko Kamenov
Dec 8, 2017·Diabetology & Metabolic Syndrome·Marta Izabela JonasMonika Puzianowska-Kuznicka
Oct 20, 2018·Current Diabetes Reports·Thomas Reinehr, Christian Ludwig Roth
May 22, 2016·Diabetes Care·Clemens WittenbecherMatthias B Schulze
Jan 23, 2019·Frontiers in Physiology·Cynthia Aparecida de CastroAna Cláudia Garcia de Oliveira Duarte
Jul 6, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Thomas Reinehr
May 24, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Juliana NyasordziAnette E Buyken
Jan 6, 2022·The International Journal of Lower Extremity Wounds·Tsvetan GatevZdravko Kamenov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.