Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages.

American Journal of Physiology. Heart and Circulatory Physiology
Fina LovrenSubodh Verma

Abstract

Altered macrophage kinetics is a pivotal mechanism of visceral obesity-induced inflammation and cardiometabolic risk. Because monocytes can differentiate into either proatherogenic M1 macrophages or anti-inflammatory M2 macrophages, approaches that limit M1 while promoting M2 differentiation represent a unique therapeutic strategy. We hypothesized that adiponectin may prime human monocytes toward the M2 phenotype. Adiponectin promoted the alternative activation of human monocytes into anti-inflammatory M2 macrophages as opposed to the classically activated M1 phenotype. Adiponectin-treated cells displayed increased M2 markers, including the mannose receptor (MR) and alternative macrophage activation-associated CC chemokine-1. Incubation of M1 macrophages with adiponectin-treated M2-derived culture supernatant resulted in a pronounced inhibition of tumor necrosis factor-alpha and monocyte chemotactic protein-1 secretion. Activation of human monocytes into M2 macrophages by adiponectin was mediated, in addition to AMP-activated protein kinase and peroxisome proliferator-activated receptor (PPAR)-gamma, via PPAR-alpha. Furthermore, macrophages isolated from adiponectin knockout mice demonstrated diminished levels of M2 markers suc...Continue Reading

References

Apr 15, 2000·Nature·J M Friedman
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·K HottaY Matsuzawa
Jul 26, 2002·The Journal of Biological Chemistry·Morihiro MatsudaYuji Matsuzawa
Aug 2, 2002·The Journal of Biological Chemistry·Ke MaLawrence Chan
Dec 4, 2002·Nature Reviews. Immunology·John SavillChris Haslett
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Jan 11, 2003·The American Journal of Cardiology·Ishwarlal Jialal, Sridevi Devaraj
Jan 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Masahiro KumadaUNKNOWN Osaka CAD Study Group. Coronary artery disease
May 9, 2003·American Journal of Physiology. Endocrinology and Metabolism·Jens M BruunBjorn Richelsen
Jun 13, 2003·Nature·Toshimasa YamauchiTakashi Kadowaki
Aug 29, 2003·The Journal of Biological Chemistry·Hui ChenMichael J Quon
Oct 22, 2003·Circulation·Paul E SzmitkoSubodh Verma
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Tobias PischonEric B Rimm
Jan 18, 2005·American Journal of Physiology. Heart and Circulatory Physiology·David C W LauSubodh Verma
Nov 22, 2005·Clinical and Experimental Immunology·F PorcherayG Gras
Sep 26, 2006·Nature Reviews. Immunology·Herbert Tilg, Alexander R Moschen
Dec 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Paul E SzmitkoSubodh Verma
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Jan 27, 2007·The Journal of Clinical Investigation·Yukihiro TakemuraKenneth Walsh
Jul 17, 2007·Biochimica Et Biophysica Acta·Fokko Zandbergen, Jorge Plutzky
Nov 1, 2007·European Journal of Immunology·Siamon Gordon
May 3, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Sridevi DevarajIshwarlal Jialal
Jun 6, 2009·European Journal of Clinical Investigation·D SporrerC Buechler
Dec 24, 2009·The Journal of Biological Chemistry·Koji OhashiKenneth Walsh
Jan 13, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Peter LibbyEduardo Folco
Mar 5, 2010·Clinical Pharmacology and Therapeutics·P MathieuJ-P Després

❮ Previous
Next ❯

Citations

Jun 27, 2013·Molecular Neurobiology·Dah-Yuu LuYueh-Hsiung Kuo
Jul 4, 2012·Pulmonary Pharmacology & Therapeutics·Benjamin D Medoff
Sep 6, 2012·The Journal of Biological Chemistry·Xiang ChengPeter Libby
Aug 10, 2011·Current Opinion in Lipidology·Giulia Chinetti-Gbaguidi, Bart Staels
Mar 19, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Sridevi Devaraj, Ishwarlal Jialal
Nov 21, 2013·Acta Neuropathologica Communications·Jeroen F J BogieJerome J A Hendriks
Apr 17, 2012·Journal of Lipid Research·Ingrid Wernstedt AsterholmPhilipp E Scherer
May 2, 2012·Endocrine Reviews·Maria DalamagaChristos S Mantzoros
May 24, 2011·Parkinson's Disease·Anna R CartaEzio Carboni
Jan 15, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Jennifer L Parker-Duffen, Kenneth Walsh
Apr 22, 2014·Trends in Endocrinology and Metabolism : TEM·Koji OhashiNoriyuki Ouchi
Jul 19, 2013·Journal of Allergy·Norah G VerboutStephanie A Shore
Apr 12, 2011·Digestive Diseases and Sciences·Violeta ArsenescuRazvan Arsenescu
Jun 23, 2012·Canadian Journal of Physiology and Pharmacology·Crystal RocherDinender K Singla
Aug 16, 2011·Current Opinion in Lipidology·Samantha Adamson, Norbert Leitinger
Dec 31, 2015·Cardiovascular Research·Mizuho Hiramatsu-ItoNoriyuki Ouchi
Jun 21, 2012·Biochimie·Koji OhashiYuji Matsuzawa
Mar 9, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M Dall'AstaD Del Rio
Dec 30, 2015·PPAR Research·Amanda CroasdellRichard P Phipps
Apr 5, 2011·British Journal of Pharmacology·Xiaoyan HuiAimin Xu
Apr 18, 2013·Diabetes/metabolism Research and Reviews·Michael R FlockPenny M Kris-Etherton
Jan 22, 2013·Journal of Cellular Physiology·Dler Faieeq Darweesh MahmoodKhadija El Hadri
Apr 3, 2014·American Journal of Reproductive Immunology : AJRI·Leonardo T L MedeirosMaria T S Peraçoli
Jan 23, 2016·Cardiovascular Research·Kaho WatanabeTakuya Watanabe
Feb 13, 2014·Annals of the New York Academy of Sciences·E Rand Sutherland
Oct 17, 2014·Immunological Reviews·Sophie ColinBart Staels
Oct 17, 2014·Immunological Reviews·Andrea A HillAlyssa H Hasty
Jan 15, 2015·Clinical and Experimental Pharmacology & Physiology·Miron SopićZorana Jelić-Ivanović
Mar 20, 2016·Journal of Molecular Cell Biology·Hong Ruan, Lily Q Dong
Apr 16, 2016·Cytokine & Growth Factor Reviews·Ganji Purnachandra NagarajuSubasini Pattnaik
Feb 20, 2015·International Journal of Cancer. Journal International Du Cancer·Jiao PengYan Chen
Oct 3, 2013·Molecular Immunology·Takaharu NegoroYasuko Nakano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here