Adiponectin regulates bone mass in AIS osteopenia via RANKL/OPG and IL6 pathway

Journal of Translational Medicine
Hongqi ZhangGuanteng Yang

Abstract

Osteopenia have been well documented in adolescent idiopathic scoliosis (AIS). Adiponectin has been shown to be inversely proportional to body mass index and to affect bone metabolism. However, the circulating levels of adiponectin and the relationship between adiponectin and low bone mass in AIS remain unclear. A total of 563 AIS and 281 age-matched controls were recruited for this study. Anthropometry and bone mass were measured in all participants. Plasma adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA) in the AIS and control groups. An improved multiplex ligation detection reaction was performed to study on single nucleotide polymorphism. Facet joints were collected and used to measure the microstructure, the expression of RANKL, OPG, osteoblast-related genes, inflammatory factors, adiponectin and its receptors by qPCR, western blotting and immunohistochemistry. Furthermore, primary cells were extracted from facet joints to observe the reaction after adiponectin stimulation. Compared with the controls, lower body mass index and a marked increase in circulating adiponectin were observed in AIS osteopenia (17.09 ± 1.09 kg/m2 and 21.63 ± 10.30 mg/L). A significant difference in the presence of rs...Continue Reading

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Citations

Oct 8, 2020·Development·Michel Bagnat, Ryan S Gray
Aug 14, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhuo-Tao LiangHong-Qi Zhang

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
X-ray
PCR
protein assay
genotyping
transgenic

Software Mentioned

SPSS

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