Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Daniel A OstlerDoina Ivan

Abstract

Adipophilin is a monoclonal antibody against a protein on the surface of intracellular lipid droplets, and it was recently shown to be expressed in sebocytes and sebaceous lesions. This study examines adipophilin expression in various sebaceous lesions and other cutaneous tumors with a clear cell histology that may mimic sebaceous differentiation. A total of 117 cutaneous clear cell lesions including 16 sebaceous adenomas, 25 sebaceous carcinomas, 8 basal cell carcinomas, 12 squamous cell carcinomas, 6 xanthomas, 10 xanthelasmas, 10 xanthogranulomas, 4 balloon cell nevi, 5 trichilemmomas, 8 clear cell hidradenomas, and 13 metastatic renal cell carcinomas were examined using immunohistochemistry for the expression of adipophilin. Of these 117 lesions, 42 (36%) were from the periocular region. Adipophilin was expressed in 16 of 16 (100%) sebaceous adenomas, 23 of 25 (92%) sebaceous carcinomas, 10 of 10 (100%) xanthelasmas, 9 of 10 (90%) xanthogranulomas, 6 of 6 (100%) xanthomas, and 9 of 13 (62.5%) metastatic renal cell carcinomas. The characteristic staining pattern differed between sebaceous and non-sebaceous tumors with the former showing a membranous vesicular pattern and the latter being more granular. Adipophilin expression...Continue Reading

References

May 1, 1989·Survey of Ophthalmology·L G Kass, A Hornblass
Jan 1, 1985·Ophthalmic Plastic and Reconstructive Surgery·R P Yeatts, R R Waller
Jun 1, 1984·Journal of Cutaneous Pathology·J Civatte
Aug 1, 1984·The American Journal of Surgical Pathology·J T WolfeR R Waller
Feb 1, 1984·Archives of Ophthalmology·M T Doxanas, W R Green
Jan 20, 1999·The British Journal of Ophthalmology·M ZürcherJ R Collin
Oct 27, 1999·The American Journal of Dermatopathology·I B Bayer-GarnerB Smoller
Feb 6, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Tze F LaiCraig L James
Dec 8, 2004·Ophthalmology·Jerry A ShieldsCarol L Shields
Mar 8, 2005·Survey of Ophthalmology·Jerry A ShieldsCarol L Shields
Mar 25, 2006·Journal of Clinical Pathology·K MuthusamyF Roberts
Oct 12, 2007·Biochemical and Biophysical Research Communications·Jenny PerssonMarie W Lindholm
Jan 19, 2008·Endocrinology·Nicole A Ducharme, Perry E Bickel
Aug 19, 2008·Pathology International·Miki IzumiHiroshi Goto
Jan 6, 2009·The Journal of Dermatology·Miki IzumiKiyoshi Mukai

❮ Previous
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Citations

Mar 21, 2012·Head and Neck Pathology·Douglas R Gnepp
Jul 23, 2011·The American Journal of Dermatopathology·Shin-ichi AnsaiTetsunori Kimura
Nov 25, 2011·The American Journal of Dermatopathology·Mai P Hoang
May 24, 2012·The American Journal of Dermatopathology·Inmaculada AlcarazLuis Requena
Sep 6, 2011·Journal of Medical Case Reports·Cornelia Sl MüllerClaudia Pfoehler
Sep 3, 2013·Archives of Pathology & Laboratory Medicine·Gabrielle M BakerMai P Hoang
Nov 26, 2015·Journal of Clinical Pathology·Richard DanialanDoina Ivan
Dec 18, 2013·Human Pathology·Adriano PirisMai P Hoang
Dec 3, 2013·Ophthalmology·Tatyana MilmanRalph C Eagle
Oct 12, 2013·American Journal of Ophthalmology·Frederick A Jakobiec, Pia R Mendoza
May 7, 2013·Human Pathology·Chakib BoussahmainMai P Hoang
Dec 5, 2012·Ophthalmology·Yoshihiro YonekawaAaron Fay
Oct 14, 2011·The Journal of Dermatology·Youichi OgawaShinji Shimada
Apr 5, 2014·Journal of Cutaneous Pathology·Huei-Chieh ChuangTseng-tong Kuo
Mar 30, 2016·Seminars in Diagnostic Pathology·Wajiha J KheirBita Esmaeli
Jan 23, 2015·Diagnostic Cytopathology·Deepali JainVenkateswaran K Iyer
May 24, 2015·Survey of Ophthalmology·Jordan M ThompsonSander R Dubovy
Feb 24, 2015·Clinics in Dermatology·Vivian T YinBita Esmaeli
Dec 31, 2014·Archives of Pathology & Laboratory Medicine·Tammie Ferringer
Nov 26, 2016·Journal of Cutaneous Pathology·Masakazu FujimotoShin-Ichi Murata
Mar 4, 2017·The Journal of Dermatology·Jonathan Ho, Jag Bhawan
Mar 4, 2017·The Journal of Dermatology·Shin-Ichi Ansai
Jun 3, 2017·Indian Journal of Ophthalmology·Pia R Mendoza, Hans E Grossniklaus
Mar 29, 2016·World Journal of Methodology·Mar Llamas-VelascoThomas Mentzel
Dec 2, 2017·Electrophoresis·Roshanak AslebaghCostel C Darie
Sep 5, 2018·Journal of Cutaneous Pathology·You-Na SungKyung-Ja Cho
May 10, 2018·The American Journal of Dermatopathology·Takeshi NamikiShin-Ichi Ansai
Jan 15, 2019·Archives of Pathology & Laboratory Medicine·Edward H FultonJerad M Gardner
Oct 5, 2019·The American Journal of Dermatopathology·Mariantonieta TiradoAlmut Böer-Auer
Aug 20, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Jan HrudkaDave Bandke
Apr 2, 2015·The American Journal of Dermatopathology·Ana M Molina-RuizLuis Requena
Dec 11, 2019·Histopathology·Ingrid FerreiraThomas Brenn

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