Adipose afferent reflex is enhanced by TNFα in paraventricular nucleus through NADPH oxidase-dependent ROS generation in obesity-related hypertensive rats

Journal of Translational Medicine
Lei DingYe-Bo Zhou

Abstract

The adipose afferent reflex (AAR), a sympatho-excitatory reflex, can promote the elevation of sympathetic nerve activity (SNA) and blood pressure (BP). Inflammation in the paraventricular nucleus (PVN) involves sympathetic abnormality in some cardiovascular diseases such as hypertension. This study was designed to explore the effects of tumor necrosis factor alpha (TNFα) in the PVN on the AAR and SNA in rats with obesity-related hypertension (OH) induced by a high-fat diet for 12 weeks. Renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) were continuously recorded in anesthetized rats, and their responses to capsaicin (CAP) stimulation of the right inguinal white adipose tissue were used to evaluate the AAR. Compared to the control rats, the systolic blood pressure (SBP), plasma norepinephrine (NE, indicating SNA) and TNFα levels, TNFα mRNA and protein levels, reactive oxygen species (ROS) content and NADPH oxidase activity in the PVN were significantly elevated in rats with OH. TNFα in the PVN markedly enhanced sympathoexcitation and AAR. Moreover, the enhancement of AAR caused by TNFα can be significantly strengthened by the pretreatment of diethyldithiocarbamate (DETC), a superoxide dismutase inhibitor, ...Continue Reading

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Citations

Dec 24, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carolina DalmassoAnalia S Loria
Mar 3, 2020·Frontiers in Physiology·Mark DomondonDaria V Ilatovskaya
Aug 20, 2021·Frontiers in Endocrinology·Safaa H HammoudAhmed F El-Yazbi
Aug 29, 2021·Toxicology and Applied Pharmacology·Hong-Bao LiYu-Ming Kang
Sep 11, 2021·Life Sciences·Fabiola Lilí Sarmiento-SalinasPaola Maycotte

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Methods Mentioned

BETA
enzyme-linked immunoassay
confocal microscopy
PCR

Software Mentioned

GraphPad Prism

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