Adipose-derived Mesenchymal Stem Cells in the Treatment of Obesity: A Systematic Review of Longitudinal Studies on Preclinical Evidence

Current Stem Cell Research & Therapy
Fatima SalehMarwan El Ghoch

Abstract

Obesity is an increasing global health problem, but its treatment is not yet optimal, especially in the long term. For this reason, preclinical studies have been conducted relating to a new therapeutic strategy for obesity based on adipose-derived mesenchymal stem cells (AD-MSCs). The aim of our systematic review is to summarize these findings deriving from the animal model in order to establish whether there is sufficient evidence to justify going forward to clinical studies. Literature searches, study selection, methods and quality appraisal were performed as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data were collated using a narrative approach. Of the 578 articles retrieved, seven studies met the inclusion criteria, and their analysis revealed several main findings. There was a strong evidence of the positive effect of AD-MSCs in obesity treatment in terms of body weight, glucose metabolism homeostasis, lipid profiles, non-alcoholic fatty liver disease and systemic inflammation. Moreover, there was recent evidence from a few studies for a significant effect of AD-MSCs transplantation on the improvement of obesity-related hormonal status, (i.e., leptin) and body compositi...Continue Reading

Citations

Feb 19, 2019·World Journal of Gastroenterology : WJG·Rim SerhalNada Alaaeddine
Dec 12, 2019·Frontiers in Endocrinology·Yu HuRong Yuan
Aug 1, 2020·Frontiers in Cell and Developmental Biology·Anny W RobertPatrícia Shigunov
Apr 19, 2021·Life Sciences·Gustavo C ParisAlessandra A Thole
Jan 6, 2022·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Agnieszka MikłoszAdrian Chabowski

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