Adipose-derived mesenchymal stem cells slow disease progression of acute-on-chronic liver failure

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Carlos GilsanzMaría P De Miguel

Abstract

A serious complication of chronic hepatic insufficiency is acute-on-chronic liver failure, a recognized syndrome characterized by acute decompensation of cirrhosis and organ/system failure. We investigated the use of adipose-derived mesenchymal stem cells (AD-MSCs) in an experimental model of acute-on-chronic liver failure, developed by microsurgical extrahepatic cholestasis in rats. Rats undergoing microsurgical extrahepatic cholestasis were treated by intraparenchymal liver injection of human or rat AD-MSCs, undifferentiated or previously differentiated in vitro toward the hepatocyte lineage. The groups treated with rat AD-MSCs showed less ascites, lower hepato- and splenomegaly, less testicular atrophy, and an improvement in serum biochemical hepatic parameters. There was also an improvement in histological liver changes, in which the area of fibrosis and bile duct proliferation were significantly decreased in the group treated with predifferentiated rat AD-MSCs. In conclusion, an isograft of hepatocyte-predifferentiated AD-MSCs injected intraparenchymally 2 weeks after microsurgery in extrahepatic cholestatic rats prevents secondary complications of acute-on-chronic hepatic failure. These data support the potential use of a...Continue Reading

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Citations

Jul 11, 2019·Current Transplantation Reports·Aylin AcunBasak E Uygun
Aug 26, 2018·Stem Cell Research & Therapy·Yong-Hong WangHong Tang
Dec 25, 2019·Stem Cells International·Jeanne AdiwinataPawitan

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