Abstract
To evaluate the therapeutic effect of adipose-derived regenerative cell (ADRC) administration on tendon-bone healing in a rabbit anterior cruciate ligament (ACL) reconstruction model. ACL reconstruction with semitendinosus tendon autograft was performed in the right knees of adult white rabbits. Eighty rabbits were divided into 2 groups: the treatment group, in which the graft was coated with ADRCs mixed in a fibrin glue carrier during surgery, and the control group, in which the graft was coated with fibrin glue only. At 2, 4, 6, 8, and 12 weeks postoperatively, 8 rabbits were killed in each group. Three were used for histologic evaluation at the tendon-bone interface and 5 for biomechanical examination. On histologic analysis, chondroid cells appeared more orderly and more regular in size and shape and Sharpey-like fibers, which connected the tendon graft and bone tissue, appeared earlier in ADRC-treated tissues than in control tissues. On biomechanical analysis, the ultimate failure load in the ADRC-treated group was significantly greater than that in the control group at 2 weeks (29.5 ± 7.2 N v 20.9 ± 2.7 N, P = .016) and 4 weeks (32.3 ± 3.9 N v 22.8 ± 5.4 N, P = .016). Stiffness was significantly higher in the ADRC-treated...Continue Reading
References
May 1, 1989·The American Journal of Sports Medicine·S C ShoemakerM Sanchez
Apr 17, 2001·Tissue Engineering·P A ZukM H Hedrick
Jul 2, 2003·Cells, Tissues, Organs·Daniel A De UgarteMarc H Hedrick
Nov 5, 2004·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Jit-Kheng LimEng-Hin Lee
Nov 24, 2004·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Stefan LendeckelHans-Peter Howaldt
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·John K FraserMarc H Hedrick
Apr 29, 2006·The Journal of Bone and Joint Surgery. British Volume·T KanazawaK Nagata
Jul 29, 2006·Stem Cells·Rosa YañezJuan A Bueren
Apr 3, 2007·The American Journal of Sports Medicine·Michael Y H SoonE H Lee
Apr 7, 2007·Plastic and Reconstructive Surgery·Gino RigottiAndrea Sbarbati
May 15, 2007·Circulation Research·Jeffrey M GimbleBruce A Bunnell
Jun 20, 2007·Aesthetic Plastic Surgery·Fabrício Carvalho TorresMarcus Castro Ferreira
Aug 13, 2008·International Journal of Colorectal Disease·Damian Garcia-OlmoMariano Garcia-Arranz
Jun 11, 2009·The American Journal of Sports Medicine·Max EkdahlFreddie H Fu
Nov 17, 2009·The Breast Journal·Kotaro YoshimuraKiyonori Harii
Jan 26, 2010·Annals of Plastic Surgery·Min ZhuHai-Chien Kuo
Feb 2, 2010·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Junsuke NakaseKatsuro Tomita
Oct 6, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Zheng FengKai Pinkernell
Apr 20, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Yong-Gang LiGao-Jun Teng
Jul 13, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Chiaki NakanishiMasakazu Yamagishi
Nov 18, 2011·The American Journal of Sports Medicine·Eiji KondoHarukazu Tohyama
Jun 27, 2012·Cell Transplantation·Yutaka MifuneJohnny Huard
Sep 6, 2012·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Seigo SuganumaHiroyuki Tsuchiya
Jan 24, 2014·The American Journal of Sports Medicine·Pauline Po Yee LuiYuk Wa Lee
Jun 24, 2014·American Heart Journal·Emerson C PerinFrancisco Fernández-Avilés
Nov 2, 2014·In Vitro Cellular & Developmental Biology. Animal·Yeonsue JangJin Woo Lee
Jan 8, 2015·Regenerative Medicine·Deborah StancoLaura de Girolamo
Feb 5, 2015·Journal of Visualized Experiments : JoVE·Elizabeth R ZielinsDerrick C Wan
Citations
Mar 29, 2018·The Bone & Joint Journal·A T HexterF S Haddad
Mar 15, 2019·The American Journal of Sports Medicine·Can ChenHongbin Lu
Jul 16, 2019·The American Journal of Sports Medicine·Yaying SunShiyi Chen
May 1, 2019·Tissue Engineering. Part B, Reviews·Isabel CalejoManuela E Gomes
Nov 1, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yuichi KurodaRyosuke Kuroda
Sep 1, 2019·Journal of Orthopaedic Surgery·Eduard Alentorn-GeliRamón Cugat
Oct 21, 2020·BMC Musculoskeletal Disorders·Tomoharu TakagiHiroyuki Tsuchiya
Jan 5, 2021·Biomaterials·Xuan HeLing Qin
Nov 5, 2020·Proceedings of the National Academy of Sciences of the United States of America·Paulos Y MengsteabCato T Laurencin
Mar 16, 2021·Journal of Orthopaedic Translation·Wangping DuanXiaochun Wei
Aug 10, 2021·World Journal of Stem Cells·Yue XuGuo-Xin Ni
Aug 13, 2021·Stem Cells International·Canlong WangWeiliang Shen
Jan 9, 2019·ACS Applied Materials & Interfaces·Can ChenHongbin Lu
Aug 22, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xibang ZhaoJiali Wang
Oct 14, 2021·The American Journal of Sports Medicine·Tatsuaki MatsumotoTakeshi Miyamoto
Nov 16, 2021·Stem Cell Research & Therapy·Kai TieLiaobin Chen