Adipose-derived stem cells for treatment of chronic ulcers: current status

Stem Cell Research & Therapy
Jens Selch HolmJens Ahm Sorensen

Abstract

Chronic ulcers remain a difficult challenge in healthcare systems. While treatment options are limited, stem cells may be a novel alternative. Adipose-derived stem cells (ADSC) have become increasingly popular compared with bone marrow-derived stem cells as they are far easier to harvest. To summarize the current status of treating chronic ulcers with ADSC, this systematic review includes all clinical trials on the subject from PubMed and EmBase, as well as all registered clinical trials on ClinicalTrials.Gov. A total of nine clinical trials and fourteen registered trials were included. The studies were significantly different in terms of study design and patient population, and the overall quality of the studies was low to moderate. Despite the overall low study quality and the significant differences between the studies, some conclusions were consistent: ADSCs are safe, improve the healing of chronic ulcers, and reduce pain. As these results are consistent despite the shortcomings of the studies, they appear to highlight the efficacy of ADSCs in the treatment of chronic ulcers. Larger numbers of higher quality studies are needed to determine the precise role of ADSCs in treating chronic leg ulcers.

References

Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Feb 6, 2007·Clinics in Dermatology·Nathan B MenkeRobert F Diegelmann
Apr 24, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Regina RennerKurt Seikowski
May 16, 2009·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Hiroshi Mizuno
Feb 9, 2010·Journal of Dental Research·S Guo, L A Dipietro
May 25, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Seung-Kyu HanWoo-Kyung Kim
Jan 5, 2011·Annals of Plastic Surgery·Mario CherubinoKacey G Marra
Jun 9, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Julia EscandonRobert S Kirsner
Apr 14, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Han Cheol LeeJin Sup Jung
Nov 20, 2012·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Ramesh Kumar Sharma, Jerry R John
Apr 3, 2014·Annals of Plastic Surgery·Navid Mohamadpour ToyserkaniJens Ahm Sørensen
May 23, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Waqar Ul HassanWenxin Wang
Jun 29, 2015·Clinics in Plastic Surgery·Sydney R Coleman, Evan B Katzel
Jun 21, 2017·Journal of Translational Medicine·Adas DarinskasRytis Rimdeika
Jul 14, 2017·Annals of Medicine and Surgery·Nicolò BertozziEdoardo Raposio
Jul 20, 2017·Stem Cells Translational Medicine·Navid Mohamadpour ToyserkaniJens Ahm Sørensen
Jul 27, 2017·Dermatology : International Journal for Clinical and Investigative Dermatology·M ChopinaudA Dompmartin
Sep 21, 2017·World Journal of Stem Cells·Reza Tabatabaei Qomi, Mohsen Sheykhhasan
Nov 2, 2017·Wounds : a Compendium of Clinical Research and Practice·Eftychia PlatsidakiChristos Christodoulou

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Citations

Apr 26, 2019·Journal of Cellular and Molecular Medicine·Bin FangQingfeng Li
Sep 24, 2019·Expert Opinion on Biological Therapy·Isabel AndiaNatalia Burgos-Alonso
Aug 28, 2020·World Journal of Stem Cells·Anjali C RaghuramAlex K Wong
Jan 6, 2019·Nature Reviews. Molecular Cell Biology·Alexandra L Ghaben, Philipp E Scherer
Oct 28, 2019·Clinical Science·Tongxing Song, Shihuan Kuang
Apr 15, 2020·Advances in Wound Care·Jean-Benoît Monfort, Patricia Senet
Jan 26, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hwa Seung HanJae Hyung Park
Jun 29, 2021·The International Journal of Lower Extremity Wounds·Johannes EschbornMojtaba Ghods
Jul 15, 2021·Advances in Skin & Wound Care·Tarun SahuRamanjan Sinha
Aug 28, 2021·International Journal of Molecular Sciences·Shao-Chun WuChing-Hua Hsieh
Jul 2, 2019·Cells, Tissues, Organs·Alessia PaganelliCristina Magnoni
Jan 13, 2022·The International Journal of Lower Extremity Wounds·Komal SaeedSundas Javed

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Methods Mentioned

BETA
amputation
amputations

Clinical Trials Mentioned

NCT01663376
NCT00815217
NCT01745744
NCT02304588
NCT01932021
NCT02092870
NCT02145897
NCT02831075
NCT02375802
NCT02864654

Software Mentioned

Angiolipo
Covidence

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